lactacystin

Name

lactacystin

Synonym

Description

Lactacystin, an antibiotic Streptomyces spp. metabolite, is a potent and selective proteasome inhibitor with an IC50 of 4.8 μM for 20S proteasome. Lactacystin also inhibits the lysosomal enzyme cathepsin A[1]. Lactacystin inhibits cell growth and induces neurite outgrowth[2].

Related Catalog

Target

IC50: 4.8 μM (proteasome)[1]

In Vivo

Lactacystin (microinjection; 2 µg) induces a Parkinson’s disease-like motor phenotype 5-7 days after injection in young and adult mice[2]. Animal Model: Male C57Bl/6RccHsd mice with 8-9 weeks (young) and 12-14 months (adult) old[2] Dosage: 2 µg Administration: Microinjection Result: Induced a Parkinson’s disease-like motor phenotype 5-7 days after injection in young and adult mice.

References

[1]. Csizmadia V, et al. Effect of proteasome inhibitors with different chemical structures on the ubiquitin-proteasomesystem in vitro. Vet Pathol. 2010 Mar;47(2):358-67.

[2]. Savolainen MH, et al. Nigral injection of a proteasomal inhibitor, lactacystin, induces widespread glial cell activationand shows various phenotypes of Parkinson's disease in young and adult mouse. Exp Brain Res. 2017 Jul;235(7):2189-2202.

Density

1.4±0.1 g/cm3

Boiling Point

714.9±60.0 °C at 760 mmHg

Melting Point

233-235ºC dec.

Molecular Formula

C15H24N2O7S

Molecular Weight

376.425

Flash Point

386.1±32.9 °C

Exact Mass

376.130432

PSA

178.33000

LogP

-1.10

Vapour Pressure

0.0±5.2 mmHg at 25°C

Index of Refraction

1.560

Storage condition

−20°C

Personal Protective Equipment

Eyeshields;G