Mitoxantrone
| Price | USD1.00 |
| Packge | 1ASSAYS |
- Min. Order:1ASSAYS
- Supply Ability:per week 100kg
- Time:2019-09-11
Product Details
- Product Name Mitoxantrone
- CAS No.65271-80-9
- EINECS No.1533716-785-6
- MFC13H20O
- MW192.3
- InChIKeyPSQYTAPXSHCGMF-UHFFFAOYSA-N
- AppearanceLiquidClear slightly yellow to yellow
- Melting point -49°C
- Water Solubility SLIGHTLY SOLUBLE
- density 0.945 g/mL at 25 °C(lit.)
- storage temp. Inert atmosphere,2-8°C
- Boiling point 126-128 °C12 mm Hg(lit.)
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Mitoxantrone Basic information
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Product Name:
Synonyms:
MITOXANTRONE;1,4-dihydroxy-5,8-bis(2-((2-hydroxyethyl)amino)ethylamino)-9,10-anthracenedi;1,4-dihydroxy-5,8-bis[2-(2-hydroxyethylamino)ethylamino]-anthracene-9,10-dione;MitoxantroneBase;Mitoxantrone Hcl 70476-82-3 / Base;PharmasubstanceEP4;1,4-Dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]-9,10-anthracenedione;NSC-27983
CAS:
MF:
C22H28N4O6
MW:
444.48
EINECS:
1533716-785-6
Product Categories:
Mol File:
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Mitoxantrone Chemical Properties
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Melting point
170-1740C
Boiling point
554.47°C (rough estimate)
density
1.3049 (rough estimate)
refractive index
1.6500 (estimate)
storage temp.
-20°C Freezer
pka
pKa 5.99 (Uncertain);8.13 (Uncertain)
CAS DataBase Reference
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Safety Information
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Hazard Codes
Risk Statements
Safety Statements
WGK Germany
3
RTECS
CB5748500
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Mitoxantrone Usage And Synthesis
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Chemical Properties
Dark Blue Crystalline Solid
Uses
A DNA intercalating drug. Inhibits DNA synthesis. Used as an anti-cancer agent
Uses
Mitoxantrone is a DNA intercalating drug. Mitoxantrone inhibits DNA synthesis. Mitoxantrone is used as an anti-cancer agent.
Indications
Mitoxantrone (Novantrone) is a synthetic anthraquinone that is structurally and mechanistically related to the anthracyclines. It intercalates with DNA and produces single- strand DNA breakage. It is cross-resistant with doxorubicin in multidrug-resistant cells and in patients who have failed to respond to doxorubicin therapy.
Mitoxantrone is active against breast carcinomas, leukemias, and lymphomas. Its antitumor efficacy in patients with breast cancer is slightly lower than that of doxorubicin. Its major toxicity is myelosuppression; mucositis and diarrhea also may occur. Mitoxantrone produces less nausea, alopecia, and cardiac toxicity than does doxorubicin.
Mitoxantrone is active against breast carcinomas, leukemias, and lymphomas. Its antitumor efficacy in patients with breast cancer is slightly lower than that of doxorubicin. Its major toxicity is myelosuppression; mucositis and diarrhea also may occur. Mitoxantrone produces less nausea, alopecia, and cardiac toxicity than does doxorubicin.
Brand name
Novantrone (Serono).
Veterinary Drugs and Treatments
Mitoxantrone may be useful in the treatment of several neoplastic diseases in dogs and cats, including lymphosarcoma mammary adenocarcinoma, squamous cell carcinoma, renal adenocarcinoma, fibroid sarcoma, thyroid or transitional cell carcinomas, and hemangiopericytoma.
Because renal clearance of the drug is minimal (10%), it may be administered to cats with renal insufficiency much more safely than doxorubicin.
Because renal clearance of the drug is minimal (10%), it may be administered to cats with renal insufficiency much more safely than doxorubicin.
Aroma threshold values
Detection: 0.007 to 205 ppb
Taste threshold values
Taste characteristics art 10 ppm: woody, sweet, fruity, berry-like with a green berry background
General Description
Colorless to light yellow liquid with an odor of cedar wood. In very dilute alcoholic solution the odor resembles odor of violets. Used in perfumery.
Air & Water Reactions
Slightly water soluble .
Reactivity Profile
Irisone may react vigorously with oxidizing agents. May react exothermically with reducing agents to release hydrogen gas.
Health Hazard
ACUTE/CHRONIC HAZARDS: Toxic. May cause allergic reaction.
Company Profile Introduction
Henan CoreyChem Co., Ltd, based on the original Zhengzhou Cote Chemical Research Institute, be brave in absorbing highly educated talents & overseas returnees; actively responded to Zhengzhou City High-tech Zone Government’s Special Care Policy, reorganized and founded in National University of Science and Technology Park, which is a high-tech, stock enterprise of high-end chemical Custom synthesis;The park was created by the People's Government of Henan Province, and proved by Ministry of Education and the National Science & Technology, taking the construction mode of "many college a park, and common development", mainly depends on Zhengzhou University and Henan University’s scientific research and talent advantage to set up Universities, scientific research institute and enterprise scientific research achievements transformation platform, to make high-tech enterprises incubate, is the new high-tech talent gathering base, high and new technology industry enterprise radiation base, colleges and universities technological innovation base.
Henan Coreychem Co., Ltd, facing global High-tech pharmaceutical raw materials, high complex new type intermediates, fine chemicals custom synthesis, scale-up production and Rare chemicals trade. Corey have well-equipped machine, strong technical force and considerate marketing team service. We also have rich experience advantage in basic research, small scale process development, scale-up, industrial technology development & production and cost control.
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- Inquiry
- 2025-09-23
- Since:2014-12-17
- Address: No.967,15th Floor,Unit 7, Building 1, No.70 of DianChang Road, High-tech Development Zone, Zhengzho
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