Nimorazole
| Price | USD1.00 |
| Packge | 1KG |
- Min. Order:1KG
- Supply Ability:2kg
- Time:2019-09-06
Product Details
- Product NameNimorazole
- CAS No.6506-37-2
- EINECS No.229-394-4
- MFC9H14N4O3
- MW226.23
- AppearanceSolidOff-White to Yellow
- Melting point 110-111°
- Boiling point 367.84°C (rough estimate)
- density 1.2673 (rough estimate)
- storage temp. 2-8°C
Abby015
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Nimorazole Basic information
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Product Name:
Synonyms:
4-[2-(5-Nitroimidazol-1-yl)ethyl]morpholine;4-[2-(5-Nitro-1H-imidazol-1-yl)ethyl]morpholine;K-1900;Naxogin;Nitrimidazine;Nulogyl;1-(2-N-Morpholinylethyl)-5-nitroimidazole;Acterol
CAS:
MF:
C9H14N4O3
MW:
226.23
EINECS:
229-394-4
Product Categories:
Mol File:
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Nimorazole Chemical Properties
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Melting point
110-111°
Boiling point
367.84°C (rough estimate)
density
1.2673 (rough estimate)
refractive index
1.6300 (estimate)
NIST Chemistry Reference
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Safety Information
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Toxicity
LD50 orally in mice: 1530 mg/kg (Cavalleri)
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Nimorazole Usage And Synthesis
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Uses
Nimorazole is an antimicrobial with activity against anaerobic bacteria and protozoa.
Pharmaceutical Applications
An orally administered 5-nitroimidazole. It is slightly soluble in water at room temperature, soluble in alcohols, acetone and chloroform. The spectrum includes T. vaginalis, G. lamblia, E. histolytica, anaerobic bacteria and G. vaginalis. Activity against B. fragilis and Fusobacterium spp. is similar to or slightly less than that of metronidazole (mean MIC 0.25–1 mg/L).
A peak blood concentration of about 32 mg/L occurs within 2 h of a 500 mg oral dose. High concentrations are achieved in saliva and vaginal secretions. Excretion is principally via the urine where the drug appears as metabolites which display antimicrobial and antiprotozoal activity less than that of the parent drug.
It is generally well tolerated even at the high doses required in conjunction with radiotherapy for the treatment of head and neck tumors. Adverse effects are the same as those of metronidazole. Disulfiram-like reactions appear to be rare.
Clinical uses are similar to those of metronidazole. It is also used as a hypoxic radiosensitizer in the radiotherapy of head and neck tumors.
A peak blood concentration of about 32 mg/L occurs within 2 h of a 500 mg oral dose. High concentrations are achieved in saliva and vaginal secretions. Excretion is principally via the urine where the drug appears as metabolites which display antimicrobial and antiprotozoal activity less than that of the parent drug.
It is generally well tolerated even at the high doses required in conjunction with radiotherapy for the treatment of head and neck tumors. Adverse effects are the same as those of metronidazole. Disulfiram-like reactions appear to be rare.
Clinical uses are similar to those of metronidazole. It is also used as a hypoxic radiosensitizer in the radiotherapy of head and neck tumors.
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Nimorazole Preparation Products And Raw materials
Company Profile Introduction
Henan CoreyChem Co., Ltd, based on the original Zhengzhou Cote Chemical Research Institute, be brave in absorbing highly educated talents & overseas returnees; actively responded to Zhengzhou City High-tech Zone Government’s Special Care Policy, reorganized and founded in National University of Science and Technology Park, which is a high-tech, stock enterprise of high-end chemical Custom synthesis;The park was created by the People's Government of Henan Province, and proved by Ministry of Education and the National Science & Technology, taking the construction mode of "many college a park, and common development", mainly depends on Zhengzhou University and Henan University’s scientific research and talent advantage to set up Universities, scientific research institute and enterprise scientific research achievements transformation platform, to make high-tech enterprises incubate, is the new high-tech talent gathering base, high and new technology industry enterprise radiation base, colleges and universities technological innovation base.
Henan Coreychem Co., Ltd, facing global High-tech pharmaceutical raw materials, high complex new type intermediates, fine chemicals custom synthesis, scale-up production and Rare chemicals trade. Corey have well-equipped machine, strong technical force and considerate marketing team service. We also have rich experience advantage in basic research, small scale process development, scale-up, industrial technology development & production and cost control.
- Since:2014-12-17
- Address: No.967,15th Floor,Unit 7, Building 1, No.70 of DianChang Road, High-tech Development Zone, Zhengzho
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