Product Details
- Product Name78-DIHYDROXYFLAVONE
- CAS No.38183-03-8
- EINECS No.253-812-4
- MFC15H10O4
- MW254.24
- AppearancesolidYellow or tan
- Melting point 243-246°C
- storage temp. Inert atmosphere,Room Temperature
- Boiling point 494.4±45.0 °C(Predicted)
- density 1.443±0.06 g/cm3(Predicted)
| hemical properties |
yellow solid |
| usage |
7,8-dihydroxyflavone is disubstituted flavone that acts as a small-molecule trkb agonist. 7,8-dihydroxyflavone has been shown to reverse memory deficits and bace1 elevation in a mouse model of alzheim er's disease. 7,8-dihydroxyflavone may also provide a therapeutic option in the treatment of other neorological disorders such as rett syndrome and ptsd. |
| usage |
vascular protectant, antihaemorrhagic, tyr kinase b agonist |
| biological activity |
tyrosine kinase receptor b (trkb) agonist that binds to the extracellular domain of the receptor (k d = 320 nm). inhibits glutamate-triggered apoptosis in hippocampal neurons in vitro and in vivo . |
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