Adapalene

Antiinflammatory Drug Pure Powder 98.5% Adapalene 
Anti-Acne Skin , Adapalene raw powder , Pure Adapalene  , supplier of Adapalene 

Basic Information of Adapalene

Synonyms: CD-271;Differi
Place of Origin: China
CAS: 106685-40-9
Assay: 99%min
Molecular Formula: C28H28O3
Molecular Weight: 412.52


Product Description
Adapalene is a third-generation topical retinoid primarily used in the treatment of mild-moderate acne, and is also used off-label to treat keratosis pilaris as well as other skin conditions.[1] It is effective against acne conditions where comedones are predominant.

Medical uses
It is used for the treatment of acne
There is no evidence that the cream causes problems in the baby if used during pregnancy but this use has not been well studied

Interactions
Adapalene has been shown to enhance the efficacy of topical clindamycin, although adverse effects are also increased.[3]Application of adapalene gel to the skin 3-5 minutes before application of clindamycin enhances penetration of clindamycin into the skin, which may enhance the overall efficacy of the treatment as compared to clindamycin alone
Mechanism of action
Unlike tretinoin, adapalene inhibits keratinocyte differentiation. This inhibition of keratinocyte differentiation and proliferation is responsible for adapalene's comedolytic effect. It has both exfoliating and anti-inflammatory effects. In an in vivo study, adapalene's ability to reduce comedo formation was demonstrated by a 50-60% reduction in comedo counts compared with vehicle.