Product Details
- Product Namelymecycline
- CAS No.992-21-2
- EINECS No.213-592-2
- MFC29H38N4O10
- MW602.63
- AppearanceSolidYellow to Dark Brown
- density 1.53
- Melting point 192.5°C
- Boiling point 648.97°C (rough estimate)
- storage temp. Amber Vial, -86°C Freezer, Under inert atmosphere
Heidi 413
| lymecycline Basic information |
| Product Name: |
lymecycline |
| Synonyms: |
N-lysinomethyltetracycline;Armyl;Mucomycin;N6-[[(4S)-4β-(Dimethylamino)-1,4,4aβ,5,5aβ,6,11,12a-octahydro-3,6α,10,12,12aβ-pentahydroxy-6-methyl-1,11-dioxonaphthacen-2-yl]carbonylaminomethyl]-L-lysine;Tetralisal;Tetralysal;(+)-N-(5-Amino-5-carboxypentylaminomethyl)-4-dimethylamino-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxonaphthacene-2-carboxamide;Tertamyl |
| CAS: |
992-21-2 |
| MF: |
C29H38N4O10 |
| MW: |
602.637 |
| EINECS: |
213-592-2 |
| Product Categories: |
Antibacterial;Amines;Intermediates & Fine Chemicals;Pharmaceuticals;Isotope Labelled Compounds |
| Mol File: |
992-21-2.mol |
 |
| |
| lymecycline Chemical Properties |
| Melting point |
192.5°C |
| Boiling point |
648.97°C (rough estimate) |
| density |
1.53 |
| refractive index |
1.5500 (estimate) |
| solubility |
Very soluble in water, slightly soluble in ethanol (96 per cent), practically insoluble in methylene chloride. |
| pka |
2.50±0.24(Predicted) |
| |
| lymecycline Usage And Synthesis |
| Chemical Properties |
Yellow, hygroscopic powder. |
| Originator |
Armyl,Armour Pharm. |
| Uses |
Labelled Lymecycline. A semi-synthetic antibiotic related to Tetracycline (T291400). Antibacterial. |
| Definition |
ChEBI: A tetracycline-based broad-spectrum antibiotic. It is approximately 5000 times more soluble than tetracycline base and is unique amongst tetracyclines in that it is absorbed by the "active transport" process across the intestinal wall. |
| Manufacturing Process |
Amido-N-(lysinomethyl)tetracycline hydrochloride:
To 18.3 g of L-lysine hydrochloride dissolved in 100 ml of water is added 10 ml of 37% aqueous solution of formaldehyde. To the resultant mixture is added 44.0 g of anhydrous tetracycline dissolved in 500 ml of tetrahydrofuran. After thorough mixing the product forms over a period of about 15 min as an oily layer which after separation from the aqueous phase is added dropwise to 3 L of stirred isopropyl alcohol. The product after recovery by filtration, is reslurried with acetone, filtered and dried at 65°C at reduced pressure.
The product thus obtained has a bioassay of 500 mcg/mg (K. pneumonlae oxytetracyoline assay). |
| Therapeutic Function |
Antibiotic |
| Pharmaceutical Applications |
2-N-lysinomethyl-tetracycline. A water-soluble prodrug of tetracycline available for oral administration.
Its antimicrobial activity is due to the tetracycline content. It is lipophilic, rapidly absorbed from the gastrointestinal tract and widely distributed. Concentrations around 1 mg/kg have been found in maxillary sinus tissue some 3 h after administration of a conventional dose. The half-life is 7–14 h. Approximately 30% of an orally administered dose is excreted as active drug in the urine, where it achieves concentrations of 300 mg/L.
Its untoward effects and clinical uses are those of tetracycline, although it is claimed to be better tolerated. |
| |
| lymecycline Preparation Products And Raw materials |
Company Profile
Introduction
Technology research and transfer of pilot screening, pilot scale-up and mass production solutions , for pharmaceutical intermediates, biologicals and fine chemicals (Not including inflammable , explosive , hazardous goods ) ; Market : Nano material , metal catalyst , raw material of cosmetics , pharmaceutical intermediates , chemicals , photoelectric material , import and export of technology and goods (For projects subject to approval according to law, business activities can be carried out only after approval by relevant departments ).
