Zopiclone N-oxide
Synonym(s):(5RS)-6-(5-Chloropyridin-2-yl)-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-yl 4-methylpiperazine-1-carboxylate 4-oxide;Zopiclone oxide
- CAS NO.：43200-96-0
- Empirical Formula: C17H17ClN6O4
- Molecular Weight: 404.81
- MDL number: MFCD00871938
- EINECS: 641-896-9
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-10-27 18:05:14
What is Zopiclone N-oxide?
Chemical properties
Off-White to Pale Beige Solid
The Uses of Zopiclone N-oxide
A metabolite of Zopiclone
The Uses of Zopiclone N-oxide
Eszopiclone impurity A.
General Description
Zopiclone N-oxide is a primary, active metabolite of zopiclone in urine as well as a major pharmaceutical impurity of zopiclone known as eszopiclone impurity A. The parent drug, zopiclone, is a non-benzodiazepine hypnotic sold under the trade names Imovane?and ZImovane?and is used in the treatment of insomnia.
Properties of Zopiclone N-oxide
| Melting point: | >140°C (dec.) |
| Flash point: | 9℃ |
| storage temp. | 2-8°C |
| solubility | Chloroform (Slightly, Heated), DMSO (Slightly), Methanol (Slightly, Heated, Soni |
| pka | 4.92±0.20(Predicted) |
| form | neat |
| color | White to Light Brown |
Safety information for Zopiclone N-oxide
| Signal word | Danger |
| Pictogram(s) |
 Flame Flammables GHS02  Skull and Crossbones Acute Toxicity GHS06  Health Hazard GHS08 |
| GHS Hazard Statements |
H225:Flammable liquids H370:Specific target organ toxicity, single exposure |
| Precautionary Statement Codes |
P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P233:Keep container tightly closed. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. |
Computed Descriptors for Zopiclone N-oxide
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![6-(5-Chloro-2-pyridyl)-6,7-dihydro-7-hydroxy-5H-pyrrolo[3,4-b]pyrazin-5-one](https://img.chemicalbook.in/CAS/GIF/43200-81-3.gif)
![6-(5-Chloro-2-pyridyl)-5H-pyrrolo[3,4-b]pyrazine-5,7(6H)-dione](https://img.chemicalbook.in/CAS/GIF/43200-82-4.gif)
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