ZK-Thiazolidinone
- CAS NO.：891849-87-9
- Empirical Formula: C23H26F3N5O2S
- Molecular Weight: 493.55
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-03-31 09:12:58
What is ZK-Thiazolidinone?
Description
ZK-Thiazolidinone, also known as TAL, is an ATP-competitive inhibitor of PLK1. In vitro, ZK-Thiazolidinone counteracts the role of Plk1 in previously established functions, notably, sister chromatid separation, centrosome maturation, and bipolar spindle assembly. In vivo, ZK-Thiazolidinone selectively inhibits PLK1 and causes a prometaphase-like mitotic (G2–M) arrest. ZK-Thiazolidinone inhibits human PLK1 (IC50, 19± 12 nM) and various human and mouse tumor cell lines (IC50, 0.2–1.3 μM). ZK-Thiazolidinone impairs centrosome maturation.
Properties of ZK-Thiazolidinone
| Boiling point: | 604.8±55.0 °C(Predicted) |
| Density | 1.382±0.06 g/cm3(Predicted) |
| pka | 10.77±0.46(Predicted) |
Safety information for ZK-Thiazolidinone
Computed Descriptors for ZK-Thiazolidinone
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