ZK 756326
- CAS NO.：874911-96-3
- Empirical Formula: C21H28N2O3
- Molecular Weight: 356.46
- MDL number: MFCD09038571
- SAFETY DATA SHEET (SDS)
- Update Date: 2025-12-04 14:24:59
What is ZK 756326?
The Uses of ZK 756326
2-?[2-?[4-?[(3-?Phenoxyphenyl)?methyl]?-?1-?piperazinyl]?ethoxy]?-ethanol is a nonpeptide CCR8 chemokine receptor agonist that inhibits the binding of the CCR8 ligand I-309 (CCL1), with an IC(50) value of 1.8 muM (1). It is a useful compound to investigate the physiological role of CCR8 in HIV infection.
What are the applications of Application
ZK 756326 is a selective, non-peptide CCR8 chemokine receptor agonist
Biological Activity
Selective, non-peptide CCR8 chemokine receptor agonist (IC 50 values are 1.8 and 2.6 μ M for human and mouse receptors respectively). Displays no activity at CCR4, CXCR3, CXCR4 and CCR5 and shows > 28-fold selectivity over 26 other GPCRs (less selective at α 2A and 5-HT receptors). Induces chemotaxis and inhibits Env-mediated (HIV) cell-cell fusion.
Properties of ZK 756326
| storage temp. | Desiccate at RT |
| form | White solid. |
| Water Solubility | Soluble to 100 mM in water |
Safety information for ZK 756326
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for ZK 756326
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