ZEBULARINE

Synonym(s):1-(β-D-Ribofuranosyl)-1,2-dihydropyrimidin-2-one, 2-Pyrimidone-1-β-D-riboside;Zebularine - CAS 3690-10-6 - Calbiochem

CAS NO.：3690-10-6
Empirical Formula: C9H12N2O5
Molecular Weight: 228.2
MDL number: MFCD04973699
EINECS: 2017-001-1
SAFETY DATA SHEET (SDS)
Update Date: 2026-06-03 11:24:09

What is ZEBULARINE?

Description

Zebularine (3690-10-6) is an orally active DNA methyltransferase inhibitor. Inhibits tumor cell proliferation (IC50 = 120 μM) and re-activates silenced genes in T24 bladder carcinoma cells. Zebularine inhibits cytidine deaminase (Ki ~ 2 μM and; induces differentiation of mesenchymal stem cells into cardiomyocytes.

Chemical properties

White Solid

The Uses of ZEBULARINE

It is a cytidine analogue, cytidine deaminase inhibitor, and DNA demethylating agent

The Uses of ZEBULARINE

It is a cytidine analogue, cytidine deaminase inhibitor, and DNA demethylating agent.

What are the applications of Application

Zebularine is an inhibitor of DNA methyltransferase (Dnmt)

Definition

ChEBI: Zebularine is a member of pyrimidine ribonucleosides.

Biological Activity

Orally active DNA methyltransferase inhibitor. Inhibits tumor cell proliferation (IC 50 = 120 μ M) and re-activates silenced genes in T24 bladder carcinoma cells. Also inhibits cytidine deaminase (K i ~ 2 μ M).

Biochem/physiol Actions

Zebularine is a cytidine analogue, cytidine deaminase inhibitor, and DNA demethylating agent.

Storage

Desiccate at RT

Properties of ZEBULARINE

Melting point:	160-162?C
Boiling point:	499.0±55.0 °C(Predicted)
Density	1.73±0.1 g/cm3(Predicted)
storage temp.	2-8°C
solubility	DMSO: 16 mg/mL, soluble
form	solid
pka	13.48±0.70(Predicted)
color	White
Stability:	Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 1 month.

Safety information for ZEBULARINE

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H320:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P330:Rinse mouth. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.