YW3-56

CAS NO.：1374311-17-7
Empirical Formula: C27H32ClN5O2
Molecular Weight: 494.03
MDL number: MFCD31746906
Update Date: 2023-05-21 10:59:17

What is YW3-56?

Description

YW3-56 is a potent peptidylarginine deiminase (PAD) inhibitor, with an IC50 of 1-5 μM for PAD4.

Compared with Cl-amidine, YW3-56 shows >60-fold increase in cell growth inhibition efficacy (IC50 about 2.5 μM) but only 5-fold increase in PAD4 inhibition (IC sub>50 about 1-5 μM). At 2-4 μM concentrations, YW3-56 displays mainly cytostatic effects by slowing cell division, whereas at higher concentrations, it exerts cytotoxic effects by altering cell morphology and killing cells[1].

References

[1]. Wang Y, et al. Anticancer peptidylarginine deiminase (PAD) inhibitors regulate the autophagy flux and t he mammalian target of rapamycin complex 1 activity. J Biol Chem. 2012 Jul 27;287(31):25941-53.

Properties of YW3-56

storage temp.	Store at -20°C
solubility	Soluble in DMSO

Safety information for YW3-56

Computed Descriptors for YW3-56

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