YAP-TEAD Inhibitor 1

CAS NO.：1659305-78-8
Empirical Formula: C93H144ClN23O21S2
Molecular Weight: 2019.86
MDL number: MFCD32706886
Update Date: 2025-04-17 18:22:24

What is YAP-TEAD Inhibitor 1?

Biological Activity

YAP-TEAD Inhibitor 1 (Peptide 17) is a YAP-TEAD protein-protein interaction inhibitor which has potential usage in treatment of YAP-involved cancers with IC50 of 25 nM. The engineered peptide significantly improves the potency in disrupting YAP-TEAD interaction in vitro[1]. This 17mer peptide demonstrates a single-digit micromolar affinity to TEAD1[2].

References

[1] Zhang Z, et al. ACS Med Chem Lett. 2014, 5(9):993-998. [2] Zhou Z, et al. FASEB J. 2015, 29(2):724-732.

Properties of YAP-TEAD Inhibitor 1

Density	1.45±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
pka	4.45±0.10(Predicted)
Water Solubility	Water: 40 mg/mL (19.80 mM);

Safety information for YAP-TEAD Inhibitor 1

Computed Descriptors for YAP-TEAD Inhibitor 1

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