XRP44X
Synonym(s):[4-(3-Chlorophenyl)-1-piperazinyl](3-methyl-1-phenyl-1H-pyrazol-5-yl)-methanone;1-(3-Chlorophenyl)-4-((3-methyl-1-phenyl-1H-pyrazol-5-yl)carbonyl)piperazine;Actin Assembly Inhibitor XVI, Ras Activation Inhibitor, Tubulin Polymerization Inhibitor IX, 1-(3-Chlorophenyl)-4-((3-methyl-1-phenyl-1H-pyrazol-5-yl)carbonyl)piperazine;Ras-Net (Elk-3) Pathway Inhibitor, XRP44X - CAS 729605-21-4 - Calbiochem
- CAS NO.：729605-21-4
- Empirical Formula: C21H21ClN4O
- Molecular Weight: 380.87
- MDL number: MFCD12828749
- EINECS: 684-708-0
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-13 11:13:26
What is XRP44X?
The Uses of XRP44X
XRP44X, is a Ras-Net (Elk-3) pathway inhibitor; tubulin polymerization inhibitor Colchicine binding site.XRP44X is used as an anti-cancer drug targeting epidermal growth factor receptor.
What are the applications of Application
XRP44X is a Ras-Net (Elk-3) pathway inhibitor
Definition
ChEBI: [4-(3-chlorophenyl)-1-piperazinyl]-(5-methyl-2-phenyl-3-pyrazolyl)methanone is a member of piperazines.
General Description
A cell-permeable pyrazole compound that is shown to prevent in vitro tubulin polymerization (IC50 = 0.2 μM) by targeting Colchicine (Cat. No. 234115) binding site (Kd = 0.3 μM) in cell-free assays and induce blebs formation in HUVEC cultures by perturbing both tubulin microtubles and actin cytoskeleton structures. Unrelated to its effects on actin and tubulin filaments, XRP44X is also reported to block the activations of Ras and its downstream effector molecules, such as Raf, MEK, Erk, Rsk, and Net (Elk-3/SAP-2/Erp), upon FGF-2 (Cat. No. 341595) stimulation. Potently inhibits the growth of HUVEC, NIH3T3, as well as 9 other cancer cell lines in antiproliferation assays (IC50 ≤11.3 nM).
Biochem/physiol Actions
XRP44X is a Ras-Net (Elk-3) pathway inhibitor; tubulin polymerization inhibitor Colchicine binding site.
Properties of XRP44X
| Melting point: | 136-140 0C |
| Boiling point: | 591.1±50.0 °C(Predicted) |
| Density | 1.27±0.1 g/cm3(Predicted) |
| storage temp. | room temp |
| solubility | DMSO: ≥20mg/mL |
| pka | 1.79±0.20(Predicted) |
| form | White solid |
| color | white to off-white |
Safety information for XRP44X
Computed Descriptors for XRP44X
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