XMU-MP-1

CAS NO.：2061980-01-4
Empirical Formula: C17H16N6O3S2
Molecular Weight: 416.48
MDL number: MFCD30377214
Update Date: 2026-07-17 09:03:53

What is XMU-MP-1?

Description

XMU-MP-1 is an inhibitor of the pro-apoptotic, sterile 20-like kinases MST1 and 2 (IC₅₀s = 71.1 and 38.1 nM, respectively). It is selective for MST1 and 2 over a panel of 468 kinases at a concentration of 1 μM. XMU-MP-1 inhibits phosphorylation of MOB1, LATS1 and 2, and YAP in HepG2 cells as well as MST1 and 2 autophosphorylation in RAW 264.7, U2OS, SW480, RPE1, SNU423, and HepG2 cells in a concentration-dependent manner. It also prevents cell death induced by overexpression of MST2. XMU-MP-1 (1 mg/kg) enhances liver regeneration in mice post partial hepatectomy and reduces liver fibrosis in a mouse model of chronic liver injury.

The Uses of XMU-MP-1

XMU-?MP-?1 an MST1/2 inhibitor.

Storage

Store at -20°C

References

1. fuqin fan, zhixiang he, lu-lu kong, et al. pharmacological targeting of kinases mst1 and mst2 augments tissue repair and regeneration. science translational medicine 17 aug 2016: vol. 8, issue 352, pp. 352ra108.

Properties of XMU-MP-1

Boiling point:	714.8±70.0 °C(Predicted)
Density	1.523±0.06 g/cm3(Predicted)
storage temp.	-20°C
solubility	≥41.6 mg/mL in DMSO with gentle warming; insoluble in H2O; insoluble in EtOH
pka	9.77±0.12(Predicted)
form	powder
color	white to beige

Safety information for XMU-MP-1

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral
Precautionary Statement Codes	P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for XMU-MP-1

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