XL413 (hydrochloride)

CAS NO.：2062200-97-7
Empirical Formula: C14H13Cl2N3O2
Molecular Weight: 326.18
Update Date: 2026-02-02 18:10:39

What is XL413 (hydrochloride)?

Description

XL413 is a potent inhibitor of Cdc7 (IC₅₀ = 3.4 nM). It is >60, >10, and >300-fold selective for Cdc7 over CK2, PIM1, and a panel of over 100 protein kinases, respectively. XL413 inhibits the growth of MDA-MB-231T and COLO 205 cells (IC₅₀s = 118 and 140 nM, respectively). It inhibits Cdc7-specific phosphorylation of mini-chromosome maintenance protein (MCM2) and induces cell cycle accumulation in the S and G₂ phases in MDA-MB-231T and COLO 205 cells that overexpress Cdc7. In vivo, XL413 inhibits MCM2 phosphorylation (ED₅₀ = <3 mg/kg) and reduces tumor growth in a COLO 205 mouse xenograft model when administered orally at doses of 10, 30, and 100 mg/kg.

Properties of XL413 (hydrochloride)

storage temp.	Store at -20°C
solubility	DMSO:0.2(Max Conc. mg/mL);0.613(Max Conc. mM) PBS (pH:7.2):10.0(Max Conc. mg/mL);30.66(Max Conc. mM)
form	A crystalline solid
color	White to off-white

Safety information for XL413 (hydrochloride)

Computed Descriptors for XL413 (hydrochloride)

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