XL413 (BMS-863233)
Synonym(s):(S)-8-Chloro-2-(pyrrolidin-2-yl)benzofuro[3,2-d]pyrimidin-4(3H)-one hydrochloride;BMS-863233;XL-413
- CAS NO.：1169562-71-3
- Empirical Formula: C14H13Cl2N3O2
- Molecular Weight: 326.18
- MDL number: MFCD28023577
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-03-13 23:13:44
What is XL413 (BMS-863233)?
The Uses of XL413 (BMS-863233)
XL413 is a potent and selective cell division cycle 7 homolog (CDC7) kinase inhibitor.
Biological Activity
XL413 hydrochloride is a potent and selective cell division cycle 7 homolog (CDC7) kinase inhibitor with IC50 of 3.4 nM, its selectivity over CK2, Pim-1 and pMCM2 are 63-, 12- and 35-fold. Phase 1/2.
in vitro
In MDA-MB-231T and Colo-205 cell lines,XL413 hydrochloride inhibits CDC7-specific phosphorylation of MCM2. XL413 also inhibited cell proliferation in Colo-205 cells, decreased cell viability, and stimulated caspase 3/7 activity. Furthermore, XL413 resulted in altered S-phase progression and subsequent apoptosis.
in vivo
In the Colo-205 xenograft model, XL413, at a dose of 3 mg/kg, inhibited 70% of phosphorylated MCM2 and caused significant regression of tumor growth at a dose of 100 mg/kg.
Storage
Store at -20°C
Properties of XL413 (BMS-863233)
| storage temp. | -20°C |
| solubility | DMSO: Insoluble;Ethanol: Insoluble |
| form | powder |
| color | white to beige |
| Water Solubility | Water: 46 mg/mL (141.03 mM) |
| Stability: | Hygroscopic |
Safety information for XL413 (BMS-863233)
| Signal word | Danger |
| Pictogram(s) |
 Skull and Crossbones Acute Toxicity GHS06 |
| GHS Hazard Statements |
H301:Acute toxicity,oral |
Computed Descriptors for XL413 (BMS-863233)
New Products
Ivermectin Ep Impurity- k Cyclopropane-1,1-dicarboxylic acid [1]Benzothieno[2,3-c]pyridine, 1,7-dichloro-8-methyl- (S)-3-Fluoro-pyrrolidine hydrochloride Cyclobutylamine 1-Bromo-2-Methoxy-3-Nitrobenzene 3-Oxocyclobutane-1-carboxylicacid (4-Bromophenyl)(3,4-dimethoxyphenyl)methanone N-Nitroso hydroxy Cetrizine EP Impurity-A Noradrenaline EP Impurity D/Noradrenaline Methyl Ether Cetirizine EP Impurity A/Cetirizine CBHP Impurity Lantanoprost rc B Clidinium Bromide Impurity 2-chloro-7-cyclopentyl-N,N-dimethylpyrrolo [2,3-d]pyrimidine-6-carbox amide 4-amino-2-fluoro-N- methylbenzamide N-(2-chloropyrimidin-4-yl)-N,2,3- trimethyl-2H- indazol 6-amine 5-Chloro-3- Methyl -1,3-2-benzoxazol-2(3H)-one 4-Bromo-2-fluoro-N-methylbenzamide N-Boc-1,4-butanediamine 4-Dimethylamino pyridine 2-Chlorotrityl Chloride 4-Bromoaniline 5-Bromo-2-chlorobenzoic acid 1,2,3,9-Tetrahydro-4(H)-carbazol-4-oneRelated products of tetrahydrofuran
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