WRR483
- CAS NO.：1076088-50-0
- Empirical Formula: C29H41N7O4S
- Molecular Weight: 583.75
- Update Date: 2026-01-05 11:31:08
What is WRR483?
Description
WRR-483, an analogue of K-11777, is a potent and selective cysteine protease inhibitor with trypanocidal activity in cell culture and animal model with comparable efficacy to K11777. WRR-483 demonstrates good potency against cruzain with sensitivity to pH conditions and high efficacy in the cell culture assay. Furthermore, WRR-483 also eradicates parasite infection in a mouse model of acute Chagas' disease. WRR-483 binds covalently to the active site cysteine of the protease in a similar manner as other vinyl sulfone-based inhibitors. WRR-483 has potential to be developed as a treatment for Chagas' disease.
Safety information for WRR483
New Products
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