Wortmannin-Rapamycin Conjugate

CAS NO.：1067892-47-0
Empirical Formula: C88H131N3O23
Molecular Weight: 1598.99
Update Date: 2026-01-05 11:31:08

What is Wortmannin-Rapamycin Conjugate?

Description

Phosphoinositide 3-kinase (PI3K) and mammalian target of rapamycin (mTOR) act synergistically in promoting cancer. Wortmannin is a potent inhibitor of PI3K enzymes, while rapamycin blocks mTOR Complex 1 TORC1. Wortmannin-rapamycin conjugate consists of analogs of 17-hydroxy wortmannin and rapamycin conjugated via a prodrug linker. Hydrolysis of the prodrug linker in vivo releases the inhibitors. The wortmannin-rapamycin conjugate inhibits the growth of HT-29 colon tumors and A498 renal tumors in mice better than rapamycin alone. Also, the conjugate, when given in combination with the VEGF-blocker bevacizumab, produces substantial regression of larger A498 tumors. Finally, the wortmannin-rapamycin conjugate is tolerated better than an equivalent mixture of the inhibitors.

Properties of Wortmannin-Rapamycin Conjugate

storage temp.	Store at -20°C
solubility	DMF: 30 mg/ml; DMSO: 20 mg/ml; Ethanol: 5 mg/ml
form	A crystalline solid

Safety information for Wortmannin-Rapamycin Conjugate

Computed Descriptors for Wortmannin-Rapamycin Conjugate

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