waltonitone

CAS NO.：1252676-55-3
Empirical Formula: C30H48O2
Molecular Weight: 440.7
MDL number: MFCD34469504
Update Date: 2023-05-21 10:59:17

What is waltonitone?

The Uses of waltonitone

Waltonitone is a pentacyclic triterpenoid compound isolated from waltonione. Some studies shown that Waltonitone is a potential anti-tumor drug which can inhibit the proliferation of lung cancer A549 cells and promote their apoptosis.

Biological Activity

Waltonitone is a kind of ursane-type pentacyclic triterpenes that can be extracted from the long-stemmed chinensis, which has antitumor activity.

in vitro

waltonitone (10 μM, 25 μM; for 48 hours) results in an increment of sub-G1 population in BEL-7402 cells.
Waltonitone (25 μM; for 48 hours) induces BEL-7402 apoptosis cells.
Waltonitone (25 μM; for 48 hours) can effectively activate caspase-3 in BEL-7402 cells.

in vivo

Waltonitone (iv; 20 mg/kg or 50 mg/kg; once every two days for 16 days) inhibits BEL-7402 tumor growth in male athymic mice (BALB/c nu/nu) in vivo. < br/>

Properties of waltonitone

Boiling point:	521.6±50.0 °C(Predicted)
Density	1.05±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMSO: 15 mg/mL (34.04 mM);;
pka	15.09±0.10(Predicted)

Safety information for waltonitone

Computed Descriptors for waltonitone

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