VU6005806
- CAS NO.：2180914-37-6
- Empirical Formula: C17H16F3N7O2S
- Molecular Weight: 439.41
- MDL number: MFCD32067965
- Update Date: 2025-04-17 18:22:24
What is VU6005806?
Description
VU6005806 (AZN-00016130) is a potent muscarnic acethylcholine receptor subtype 4 (M4) positive allosteric modulator (PAM), with EC50s of 94 nM, 28 nM, 87 nM and 68 nM for human, rat, dog and cyno M4, respectively. Used in the research of neuropsychiatric disorders[1]. IC50: 94 nM (Human M4), 28 nM (Rat M4), 87 nM (Dog M4), 68 nM (Cyno M4)[1]
References
[1]. Engers DW, et al. VU6005806/AZN-00016130, an advanced M4 positive allosteric modulator (PAM) profiled as a potential preclinical development candidate. Bioorg Med Chem Lett. 2019 Jul 15;29(14):1714-1718.
Properties of VU6005806
| Density | 1.59±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | Soluble in DMSO |
| pka | 11.44±0.20(Predicted) |
Safety information for VU6005806
Computed Descriptors for VU6005806
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