VESNARINONE
- CAS NO.：81840-15-5
- Empirical Formula: C22H25N3O4
- Molecular Weight: 395.45
- MDL number: MFCD00867124
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-03-13 23:13:44
What is VESNARINONE?
Description
Vesnarinone is a new orally-active positive inotropic agent introduced for the treatment of congestive heart failure. It exerts a positive inotropic effect on the heart and has a peripheral vasodilatory effect. Vesnarinone is claimed not to affect heart rate or aggravate arrhythmia.
Description
Vesnarinone is an inhibitor of phosphodiesterase 3 (PDE3; IC50s = 10.7 and 13.2 μM for PDE3A and PDE3B, respectively). It also inhibits ether-a-go-go-related gene 1 (ERG1) channels (IC50 = 1.1 μM in HEK293T cells expressing human ERG1). Vesnarinone (3-300 μM) increases contractile tension in isolated ventricular muscles of dog, cat, rabbit, and guinea pig in a dose-dependent manner. Oral and i.v. administration of vesnarinone increases right ventricular pressure with no effect on heart rate in dog models of tricuspid insufficiency- and pulmonary stenosis-induced congestive heart failure. It also increases contractility and coronary flow while decreasing heart rate in a guinea pig model of aortic stenosis-induced congestive heart failure. Formulations containing vesnarinone have been used for the treatment of congestive heart failure.
Originator
Otsuka (Japan)
The Uses of VESNARINONE
Cardiotonic.
Definition
ChEBI: Arkin (TN) is an organic molecular entity.
brand name
Arkin (Otsuka America);Arkin-Z.
Properties of VESNARINONE
| Melting point: | 238.1-239.5° (Tominaga); mp 238.1-239.8° (Shimizu) |
| Boiling point: | 519.41°C (rough estimate) |
| Density | 1.2414 (rough estimate) |
| refractive index | 1.6500 (estimate) |
| storage temp. | Store at -20°C |
| solubility | DMSO:9.84(Max Conc. mg/mL);24.88(Max Conc. mM) DMSO:PBS (pH 7.2) (1:1):0.5(Max Conc. mg/mL);1.26(Max Conc. mM) DMF:3.0(Max Conc. mg/mL);7.59(Max Conc. mM) |
| form | A crystalline solid |
| pka | 2.86(at 25℃) |
| color | White to off-white |
Safety information for VESNARINONE
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for VESNARINONE
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