VENTURICIDIN A

CAS NO.：33538-71-5
Empirical Formula: C41H67NO11
Molecular Weight: 749.97
MDL number: MFCD00036323
EINECS: 251-568-3
SAFETY DATA SHEET (SDS)
Update Date: 2026-01-05 11:31:08

What is VENTURICIDIN A?

Description

Venturicidin A is a macrolide antibiotic isolated from strains of Streptomyces. It is active against fungi in the genus Venturia which cause apple scab, as well as other fungi, but not against higher plants. Venturicidin A is also cytotoxic against trypanosomes (IC₅₀ = 120-540 ng/ml) while being more than 25,000 times less effective against mammalian cells. It inhibits bacterial and mitochondrial ATP synthases.

The Uses of VENTURICIDIN A

Venturicidin A is an antibiotic and potent inhibitor of mitochondrial ATP synthase.

The Uses of VENTURICIDIN A

The macrolide antibiotic, Venturicidin A, isolated from a Streptomyces sp., is a potent inhibitor of mitochondrial ATP synthase complex acting on the F0 membrane sector. Venturicidin A was originally isolated as an antifungal agent.

Definition

ChEBI: Venturicidin a is a diterpene lactone.

What are the applications of Application

Venturicidin A is an antibiotic and potent inhibitor of mitochondrial ATP synthase

Properties of VENTURICIDIN A

Melting point:	145-147°; mp 140-142°
Boiling point:	874.9±65.0 °C(Predicted)
alpha	D +119° (c = 0.5 in chloroform)
Density	1.16±0.1 g/cm3(Predicted)
storage temp.	2-8°C
solubility	DMF: Soluble; DMSO: Soluble; Ethanol: Soluble; Methanol: Soluble
pka	11.80±0.70(Predicted)
form	White to off-white solid.

Safety information for VENTURICIDIN A

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection.