VEGFR2 Kinase Inhibitor II

Synonym(s):;(Z)-5-Bromo-3-(4,5,6,7-tetrahydro-1H-indol-2-ylmethylene)-1,3-dihydroindol-2-one, Vascular Endothelial Growth Factor Receptor 2 Kinase Inhibitor II, VEGFR Tyrosine Kinase Inhibitor XIII;VEGFR2 Kinase Inhibitor II - CAS 288144-20-7 - Calbiochem

CAS NO.：288144-20-7
Empirical Formula: C17H15BrN2O
Molecular Weight: 343.22
MDL number: MFCD03453583
SAFETY DATA SHEET (SDS)
Update Date: 2026-04-22 18:57:36

What is VEGFR2 Kinase Inhibitor II?

What are the applications of Application

VEGFR2 Kinase Inhibitor II is a cell permeable RTK inhibitor blocking VEGFR, FGFR, and PDGF activity.

General Description

A cell-permeable and reversible indolin-2-one class of receptor tyrosine kinase (RTK) inhibitor [IC₅₀ = 70 nM for VEGF-R2 (KDR/Flk-1), 920 nM for PDGF-Rβ, 4.92 μM for p60^c-src, and 13.3 μM for FGF-R1]. The inhibition is suggested to be competitive with respective to ATP. Also inhibits VEGF-induced (IC₅₀ = 110 nM) and PDGF-induced (IC₅₀ = 2.01 μM) cell proliferation in umbilical vein endothelial cells (HUVEC). Does not exhibit any inhibitory effect on EGF-R kinase activity (IC₅₀ >100 μM).

Biochem/physiol Actions

Cell permeable: yes

Properties of VEGFR2 Kinase Inhibitor II

storage temp.	-20C
solubility	DMF: 20 mg/ml; DMSO: 10 mg/ml
form	Brown solid

Safety information for VEGFR2 Kinase Inhibitor II

Computed Descriptors for VEGFR2 Kinase Inhibitor II

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