VEGFR2 Kinase Inhibitor II
Synonym(s):;(Z)-5-Bromo-3-(4,5,6,7-tetrahydro-1H-indol-2-ylmethylene)-1,3-dihydroindol-2-one, Vascular Endothelial Growth Factor Receptor 2 Kinase Inhibitor II, VEGFR Tyrosine Kinase Inhibitor XIII;VEGFR2 Kinase Inhibitor II - CAS 288144-20-7 - Calbiochem
- CAS NO.：288144-20-7
- Empirical Formula: C17H15BrN2O
- Molecular Weight: 343.22
- MDL number: MFCD03453583
- SAFETY DATA SHEET (SDS)
- Update Date: 2025-07-18 08:49:11
What is VEGFR2 Kinase Inhibitor II?
What are the applications of Application
VEGFR2 Kinase Inhibitor II is a cell permeable RTK inhibitor blocking VEGFR, FGFR, and PDGF activity.
General Description
A cell-permeable and reversible indolin-2-one class of receptor tyrosine kinase (RTK) inhibitor [IC50 = 70 nM for VEGF-R2 (KDR/Flk-1), 920 nM for PDGF-Rβ, 4.92 μM for p60c-src, and 13.3 μM for FGF-R1]. The inhibition is suggested to be competitive with respective to ATP. Also inhibits VEGF-induced (IC50 = 110 nM) and PDGF-induced (IC50 = 2.01 μM) cell proliferation in umbilical vein endothelial cells (HUVEC). Does not exhibit any inhibitory effect on EGF-R kinase activity (IC50 >100 μM).
Biochem/physiol Actions
Cell permeable: yes
Properties of VEGFR2 Kinase Inhibitor II
| storage temp. | -20C |
| solubility | DMF: 20 mg/ml; DMSO: 10 mg/ml |
| form | Brown solid |
Safety information for VEGFR2 Kinase Inhibitor II
Computed Descriptors for VEGFR2 Kinase Inhibitor II
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