Vardenafil hydrochloride
Synonym(s):Vardenafil hydrochloride trihydrate
- CAS NO.:224785-91-5
- Empirical Formula: C23H33ClN6O4S
- Molecular Weight: 525.07
- MDL number: MFCD07369690
- EINECS: 606-590-1
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-05-15 13:17:26
What is Vardenafil hydrochloride?
Description
Vardenafil was the second agent to be marketed and had the advantage that its onset time was not reduced by taking the medication on a full stomach . It is 30 times more potent as an inhibitor of PDE5 (mean IC50, 3.9 nM) than sildenafil and 10 times more potent than tadalafil, with a greater selectivity (>1,000 times) for human PDE5 than for human PDE2, PDE3, and PDE4 and moderate selectivity (>80 times) for PDE1. The PDE inhibitory selectivity and both the in vitro and in vivo potency of the new PDE5 inhibitor vardenafil. Vardenafil specifically inhibited the hydrolysis of cGMP by PDE5, with an IC50 of 0.7 nM (sildenafil 6.6 nM). The IC50 of vardenafil for PDE1 was 180 nM, for PDE6 11 nM, and for PDE2, PDE3 and PDE4 more than 1,000 nM.
The Uses of Vardenafil hydrochloride
vardenafil hydrochloride is a selective phsphodiesterase type 5 (pde5) inhibitor that is used as a urological agent in the treatment of erectile dysfunction.
What are the applications of Application
Vardenafil, Hydrochloride Salt is a cGMP specific phosphodiesterase type 5 (PDE 5) enzyme inhibitor.
Properties of Vardenafil hydrochloride
Melting point: | 214-216°C |
form | Solid |
color | White to Off-White Cyrstalline |
Safety information for Vardenafil hydrochloride
Signal word | Danger |
Pictogram(s) |
Skull and Crossbones Acute Toxicity GHS06 |
GHS Hazard Statements |
H301:Acute toxicity,oral H311:Acute toxicity,dermal H331:Acute toxicity,inhalation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P310:Immediately call a POISON CENTER or doctor/physician. P330:Rinse mouth. P361:Remove/Take off immediately all contaminated clothing. P302+P352:IF ON SKIN: wash with plenty of soap and water. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P405:Store locked up. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P501:Dispose of contents/container to..… |
Computed Descriptors for Vardenafil hydrochloride
InChIKey | XCMULUAPJXCOHI-UHFFFAOYSA-N |
SMILES | C(C1=NC(C)=C2C(N=C(C3C=C(S(N4CCN(CC)CC4)(=O)=O)C=CC=3OCC)NN12)=O)CC.Cl |
Abamectin manufacturer
Alembic Pharmaceuticals Limited
BDR Pharmaceuticals International Pvt Ltd
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