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HomeProduct name listVal-cit-PAB-OH

Val-cit-PAB-OH

  • CAS NO.：159857-79-1
  • Empirical Formula: C18H29N5O4
  • Molecular Weight: 379.45
  • MDL number: MFCD22381209
  • EINECS: 826-617-2
  • Update Date: 2025-07-24 18:13:45
Val-cit-PAB-OH Structural

What is Val-cit-PAB-OH?

Description

Val-Cit-PAB-OH is a peptide cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). The Val-Cit will specifically be cleaved by Cathepsin B.

The Uses of Val-cit-PAB-OH

Val-cit-PAB-OH acts as a reagent in the preparation of cell-penetrating peptidic GRP78 ligand for tumor cell-specific prodrug therapy, preparation of monomethylvaline derivative conjugates with ligands and antibodies for cancer treatment.

Properties of Val-cit-PAB-OH

Melting point: 168 °C(dec.)
Boiling point: 715.0±60.0 °C(Predicted)
Density  1.243±0.06 g/cm3(Predicted)
storage temp.  2-8°C(protect from light)
solubility  DMF: 10 mg/ml; DMSO: 10 mg/ml; PBS (pH 7.2): 1 mg/ml
form  powder to crystal
pka 13.75±0.46(Predicted)
color  White to Almost white

Safety information for Val-cit-PAB-OH

Computed Descriptors for Val-cit-PAB-OH

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