Val-Ala-PAB
- CAS NO.：1343476-44-7
- Empirical Formula: C15H23N3O3
- Molecular Weight: 293.36
- MDL number: MFCD32641649
- Update Date: 2026-04-22 18:57:36
What is Val-Ala-PAB?
Description
Val-Ala-PAB-OH is a cleavable ADC linker with a terminal hydroxyl group. The Val-Ala is effectively cleaved by lysosomal proteolytic enzymes while being highly stable in human plasma, making this a potentent stragy in ADC linker design. The hydroxyl group enables further derivatization or replacement with other reactive functional groups.
The Uses of Val-Ala-PAB
Val-Ala-PAB is a building block in the synthesis of Tesirine (a.k.a. SG3249), a clinical antibody-drug conjugate pyrrolobenzodiazepine dimer payload. Reagent in the preparation of pyrrolobenzodiazepine dimers and their antibody conjugates containing peptide linkers useful for treating proliferative including cancer.
Properties of Val-Ala-PAB
| Melting point: | 65-68°C |
| Boiling point: | 584.9±50.0 °C(Predicted) |
| Density | 1.191±0.06 g/cm3(Predicted) |
| storage temp. | -20°C, Inert atmosphere |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 13.51±0.70(Predicted) |
| color | White to Off-White |
Safety information for Val-Ala-PAB
Computed Descriptors for Val-Ala-PAB
Val-Ala-PAB manufacturer
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