URICASE
Synonym(s):Urate oxidase;Urate: oxygen oxoreductase;Urate:O2 oxidoreductase
- CAS NO.：9002-12-4
- Empirical Formula: C18H26N5O14P
- Molecular Weight: 567.397901
- MDL number: MFCD00082126
- EINECS: 232-655-5
- Update Date: 2026-04-24 14:58:50
What is URICASE?
Chemical properties
White powder
The Uses of URICASE
Uricase is very important for the determination of uric acid in biological fluids. Uricase is an important medical enzyme which can be used to determine urate in clinical analysis. The enzyme Urate oxidase (UO) catalyzes the oxidation of uric acid to 5-hydroxyisourate.
The Uses of URICASE
In the determination of serum and urine uric acid.
The Uses of URICASE
Uricase from Arthrobacter globiformis has been used for coating the electrodes in - biosensor fabrication for the detection of uric acid in urine samples. It has also been used for analysing the effect of Zn, Cu, Mg, and Mn ions on uricase.
General Description
Mice deficient in uricase develop uric acid nephropathy and diabetes insipidus which can be mitigated with recombinant uricase treatment.
Biochem/physiol Actions
Uricase catalyzes the oxidation of uric acid to 5-hydroxyisourate, which subsequently forms (S)-allantoin. It is involved in purine metabolism, urate degradation and (S)-allantoin formation .
Properties of URICASE
| storage temp. | -20°C |
| form | lyophilized powder |
| color | White to off-white |
| Water Solubility | Hardly soluble in water, slightly soluble in buffer alkaline solution. |
| Merck | 13,9944 |
| EPA Substance Registry System | Oxidase, urate (9002-12-4) |
Safety information for URICASE
| Signal word | Danger |
| Pictogram(s) |
 Health Hazard GHS08 |
| GHS Hazard Statements |
H319:Serious eye damage/eye irritation H334:Sensitisation, respiratory |
| Precautionary Statement Codes |
P202:Do not handle until all safety precautions have been read and understood. P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P308+P313:IF exposed or concerned: Get medical advice/attention. |
Computed Descriptors for URICASE
URICASE manufacturer
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