UR-PI376

CAS NO.：1192559-94-6
Empirical Formula: C17H22N6S
Molecular Weight: 342.46
Update Date: 2025-08-21 22:16:43

What is UR-PI376?

Description

UR-PI376 is a histamine H4 receptor agonist ( hH4R agonist) (pEC50 = 7.47, alpha = 0.93) showing negligible hH1R and hH2R activities and significant selectivity over the hH3R (pKB = 6.00, alpha = -0.28), as determined in steady-state GTPase assays using membrane preparations of hH(x)R-expressing Sf9 cells. Modeling of the binding mode of UR-PI376 suggests that the cyanoguanidine moiety forms charge-assisted hydrogen bonds not only with the conserved Asp-94 but also with the hH4R-specific Arg-341 residue.

Properties of UR-PI376

Boiling point:	585.0±60.0 °C(Predicted)
Density	1.20±0.1 g/cm3(Predicted)
pka	14.23±0.10(Predicted)

Safety information for UR-PI376

Computed Descriptors for UR-PI376

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