UPCDC30245

Synonym(s):1-(3-(5-Fluoro-1H-indol-2-yl)phenyl)-N-(2-(4-isopropylpiperazin-1-yl)ethyl)piperidin-4-amine

CAS NO.：1883351-01-6
Empirical Formula: C28H38FN5
Molecular Weight: 463.63
MDL number: MFCD30491881
Update Date: 2026-01-13 11:24:08

What is UPCDC30245?

Biochem/physiol Actions

UPCDC30245 is an allosteric inhibitor of AAA ATPase p97, also called valosine containing protein (VCP). p97 is an integral component of the ubiquitin fusion degradation (UFD) pathway. It plays a role in degradation of misfolded proteins, Golgi membrane reassembly, membrane transport, myofibril assembly, autophagosome maturation, and cell division, and is overexpressed in many tumor types. UPCDC30245 has an IC50 value of 27 nM, and has been shown to bind at the junction between the D1 and D2 domains of p97. UPCDC30245 has been used in cryo-ECM to show how such inhibitor binding prevents the confomational changes necessary for p97 function.

Properties of UPCDC30245

Boiling point:	647.6±55.0 °C(Predicted)
Density	1.20±0.1 g/cm3(Predicted)
storage temp.	2-8°C
form	powder
pka	16.22±0.30(Predicted)
color	white to beige

Safety information for UPCDC30245

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for UPCDC30245

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