UNC2881
- CAS NO.：1493764-08-1
- Empirical Formula: C25H33N7O2
- Molecular Weight: 463.58
- MDL number: MFCD28142814
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-04-22 18:57:36
What is UNC2881?
Description
UNC2881 is an inhibitor of Mer (IC50 = 4.3 nM), a member of the TAM family of receptor tyrosine kinases. It is selective for Mer over the remaining TAM family members Axl and TYRO3 (IC50s = 360 and 250 nM, respectively). UNC2881 inhibits phosphorylation of Mer in 697 B-ALL acute lymphoblastic leukemia cells (IC50 = 21.9 nM). It inhibits platelet aggregation and ATP release induced by type I equine fibrillar collagen in isolated human platelet-rich plasma when used at a concentration of 3 μM.
The Uses of UNC2881
UNC2881 is a specific Mer tyrosine kinase inhibitor. It inhibits collagen-stimulated platelet aggregation.
Storage
Store at +4°C
References
[1]. zhang w, mciver al, stashko ma, et al. discovery of mer specific tyrosine kinase inhibitors for the treatment and prevention of thrombosis. j med chem, 2013, 56(23): 9693-9700.
Properties of UNC2881
| Density | 1.31±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | insoluble in H2O; insoluble in EtOH; ≥13.55 mg/mL in DMSO |
| form | solid |
| pka | 12.70±0.46(Predicted) |
| color | White to off-white |
Safety information for UNC2881
Computed Descriptors for UNC2881
New Products
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