UNC2170 Maleate
- CAS NO.：1648707-58-7
- Empirical Formula: C14H21BrN2O
- Molecular Weight: 313.23
- MDL number: MFCD29770818
- Update Date: 2026-04-22 18:57:36
What is UNC2170 Maleate?
Description
UNC-2170 (1648707-58-7), identified by screening, was found to be a μM ligand for 53BP1 which also demonstrated at least 17-fold selectivity for 53BP1 over other methyl-lysine binding proteins. The DNA damage response protein 53BP1 utilizes its tandem tudor domain to recognize dimethylated lysine 20 on histone (H4K20me2), a modification associated with double-strand DNA breaks. UNC-2170 functions as a 53BP1 antagonist in cell lysates and suppresses class switch recombination in whole cells, a process requiring a functioning 53BP1 tudor domain.1
References
1) Perfetti?et al.?(2015),?Identification of a fragment-like small molecule ligand for the methyl-lysine binding protein 53BP1; ACS Chem. Biol.,?10?1072
Properties of UNC2170 Maleate
| Boiling point: | 419.6±30.0 °C(Predicted) |
| Density | 1.233±0.06 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | Soluble in DMSO (up to 40 mg/ml) or in Water (up to 50 mg/ml). |
| form | solid |
| pka | 14.63±0.46(Predicted) |
| color | White |
| Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months. |
Safety information for UNC2170 Maleate
Computed Descriptors for UNC2170 Maleate
New Products
2-Ethoxyphenol Methyl 2-methoxy-5-sulfamoylbenzoate 3,6-Dichloropyridazine Ethyl 2-chloro-2-(2-(4-methoxyphenyl)hydrazono)acetate 3,6-Dichloro-4-Isopropylpyridazine 2-[(2-Ethoxyphenoxy)methyl]oxirane 4-Morpholinoaniline 2-Chloromethyl-6-methyl-pyridine 1-Indanone tert-Butyl ((1R,2S,5S)-2-amino-5-(dimethylcarbamoyl)cyclohexyl)carbamate 2-Pyridinecarboxaldehdye 6-Methyl-2-pyridinemethanol 4-Bromo-2-fluoro-N-methylbenzamide 3-Azetidinecarboxylic acid N-(2-(4-((4-Fluorobenzyl)carbamoyl)-5-hydroxy-6-methoxypyrimidin-2-yl)propan-2-yl)-5-methyl-1,3,4-oxadiazole-2-carboxamide (R)-4-Boc-morpholine-3-carboxylic acid (Required high chiral purity NLT:99.5%) Tetrahydro-3-(2-methyl-2- nitropropyl)-2H-pyran-2-one 3-Bromo-2-fluorobenzonitrile Desoximetasone Boron Triiodide Nicotinic acid RAPAMYCIN Pentachlorobenzonitrile BudesonideRelated products of tetrahydrofuran
![N,N'-[Sulfonylbis(1,4-phenylene)]bis(chloroacetamide)](https://img.chemicalbook.in/CAS/GIF/17328-16-4.gif)
You may like
-
UNC2170 maleate >95% CAS 1648707-58-7View Details
1648707-58-7 -
UNC2170 trifluoroacetate CAS 1648707-58-7View Details
1648707-58-7 -
2-Chlorophenyl diphenyl chloromethane 99%View Details
42074-68-0 -
6-(chloromethyl)pteridine-2,4-diamine monohydrochloride 82778?08?3 99%View Details
82778?08?3 -
1,3-Dibromo-5-fluorobenzene 99%View Details
1435-51-2 -
729559-09-5 [N(E)]-N-Ethylidene-2-methyl-2-propanesulfinamide 99%View Details
729559-09-5 -
4-Isopropyl Thiophenol 4946-14-9 99%View Details
4946-14-9 -
2709271-25-8 99%View Details
2709271-25-8
Statement: All products displayed on this website are only used for non medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.