UNC2170 Maleate
- CAS NO.：1648707-58-7
- Empirical Formula: C14H21BrN2O
- Molecular Weight: 313.23
- MDL number: MFCD29770818
- Update Date: 2026-07-16 07:06:08
What is UNC2170 Maleate?
Description
UNC-2170 (1648707-58-7), identified by screening, was found to be a μM ligand for 53BP1 which also demonstrated at least 17-fold selectivity for 53BP1 over other methyl-lysine binding proteins. The DNA damage response protein 53BP1 utilizes its tandem tudor domain to recognize dimethylated lysine 20 on histone (H4K20me2), a modification associated with double-strand DNA breaks. UNC-2170 functions as a 53BP1 antagonist in cell lysates and suppresses class switch recombination in whole cells, a process requiring a functioning 53BP1 tudor domain.1
References
1) Perfetti?et al.?(2015),?Identification of a fragment-like small molecule ligand for the methyl-lysine binding protein 53BP1; ACS Chem. Biol.,?10?1072
Properties of UNC2170 Maleate
| Boiling point: | 419.6±30.0 °C(Predicted) |
| Density | 1.233±0.06 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | Soluble in DMSO (up to 40 mg/ml) or in Water (up to 50 mg/ml). |
| form | solid |
| pka | 14.63±0.46(Predicted) |
| color | White |
| Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months. |
Safety information for UNC2170 Maleate
Computed Descriptors for UNC2170 Maleate
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