UNC0321

CAS NO.：1238673-32-9
Empirical Formula: C27H45N7O3
Molecular Weight: 515.69
MDL number: MFCD18251565
EINECS: 604-604-1
SAFETY DATA SHEET (SDS)
Update Date: 2026-05-28 04:16:15

What is UNC0321?

Definition

ChEBI: 7-[2-[2-(dimethylamino)ethoxy]ethoxy]-6-methoxy-2-(4-methyl-1,4-diazepan-1-yl)-N-(1-methyl-4-piperidinyl)-4-quinazolinamine is a member of quinazolines.

Biological Activity

UNC0321 is a potent and selective histone methyltransferase G9a inhibitor with Ki of 63 pM and IC50 of 6-9 nM.It also inhibits GLP with IC50 values of 15-23 nM.UNC0321 is inactive against SET7/9, SET8/PreSET7, PRMT3 and JMJD2E.

in vitro

In G9a ECSD and CLOT assays, the IC ₅₀ values of 9 nM and 6 nM for UNC0321 (Compound 29), respectively. In GLP ECSD and CLOT assays, the IC ₅₀ values of 15 nM and 23 nM for UNC0321, respectively.
UNC0321 (Compound 3) reduces H3K9me2 levels in MDA-MB-231 cells with an IC50 of 11 μM.

Properties of UNC0321

Boiling point:	664.7±65.0 °C(Predicted)
Density	1.150±0.06 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMSO: ≥ 31 mg/mL (60.11 mM)
form	Powder
pka	9.34±0.70(Predicted)
color	White to yellow

Safety information for UNC0321

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.