UM729

CAS NO.：1448723-60-1
Empirical Formula: C20H25N5O2
Molecular Weight: 367.44
MDL number: MFCD28167784
Update Date: 2023-03-13 11:54:02

What is UM729?

Biological Activity

UM729 is an enhancer of aryl hydrocarbon receptor (AhR) antagonists.

in vitro

um729 expands normal hematopoietic stem and progenitor cells (HSPC) in an AhR-independent manner, and UM729 inhibits AML cell differentiation. In 05H163 cells, the addition of UM729 increased CD34⁺CD15^-Number of cells. It can inhibit the differentiation of most AML cells in combination with AhR antagonists.

in vivo

In NSG mice, UM729, alone or in combination with SR1, enhanced engraftment but not leukemia stem cell (LSC) frequency distribution.

Safety information for UM729

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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