UK-371804 hydrochloride
Synonym(s):2-(((4-Chloro-1-guanidino-7-isoquinolinyl)sulfonyl)amino)-isobutyric acid hydrochloride;N-[[1-[(aminoiminomethyl)amino]-4-chloro-7-isoquinolinyl]sulfonyl]-2-methyl-alanine hydrochloride;UK-371804 HCl
- CAS NO.：256476-36-5
- Empirical Formula: C14H17Cl2N5O4S
- Molecular Weight: 422.28
- MDL number: MFCD31558512
- Update Date: 2026-03-12 15:35:02
What is UK-371804 hydrochloride?
Biochem/physiol Actions
UK-371,804 is a reversible, substrate-competitive, highly potent (Ki = 10 nM) and selective urokinase-type plasminogen activator (uPA) Inhibitor with excellent selectivity over tPA, plasmin, Factor IXa and Xa. When applied topically, UK-371,80 effectively penetrates into excisional wounds of experimental pigs with no adverse effect on wound closure. UK-371,804 effectively blocks EGR-FMK from binding human uPA even in the presence of tissue proteins.
Properties of UK-371804 hydrochloride
| Melting point: | 258 °C (decomp) |
| storage temp. | -20°C |
| solubility | DMSO: 42 mg/mL (99.46 mM);Ethanol: Insoluble |
| form | powder |
| color | white to beige |
| Water Solubility | Water: Insoluble |
Safety information for UK-371804 hydrochloride
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for UK-371804 hydrochloride
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