Ubiquitination-IN-1

CAS NO.：1819330-15-8
Empirical Formula: C21H14F3N3O2S
Molecular Weight: 429.42
MDL number: MFCD31617017
Update Date: 2026-07-27 17:00:41

What is Ubiquitination-IN-1?

Biological Activity

Ubiquitination-IN-1 (compound 24) is a ubiquitination and Cksl-Skp2 protein-protein interaction (IC50=0.17 μM) inhibitor. Ubiquitination-IN-1 increases levels of p27. Ubiquitination-IN-1 has the potential for treatment disease by blocking the degradation of tumor suppressors[1]. Ubiquitination-IN-1 inhibits A549 and HT1080 cells with IC50s of 0.91 and 0.4 μM, respectively[1].

References

[1]. David Carroll, et al.Quinoline derivatives useful as ubiquitination inhibitors. WO2016025779A1.

Properties of Ubiquitination-IN-1

Boiling point:	569.2±60.0 °C(Predicted)
Density	1.441±0.06 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMSO : 83.33 mg/mL (194.06 mM; ultrasonic and warming and heat to 60°C)
form	Solid
pka	6.58±0.30(Predicted)
color	Yellow to orange

Safety information for Ubiquitination-IN-1

Computed Descriptors for Ubiquitination-IN-1

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