Tris(hydroxypropyl)phosphine
Synonym(s):THPP
- CAS NO.：4706-17-6
- Empirical Formula: C9H21O3P
- Molecular Weight: 208.24
- MDL number: MFCD00269835
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-09-12 18:49:13
What is Tris(hydroxypropyl)phosphine?
The Uses of Tris(hydroxypropyl)phosphine
Tris(hydroxypropyl)phosphine can be used as a:
- Reducing agent for the cleavage of disulfide bonds in both aqueous and buffered aqueous-organic medium.
- Ligand in the synthesis of dendritic macromolecules which are used as catalysts in heterogenizing homogeneous reactions.
- Reducing agent for the synthesis of disulfide cyclopeptides via one-pot peptide ligation-oxidative cyclization.
What are the applications of Application
THP is a disulfide reducing agent
Properties of Tris(hydroxypropyl)phosphine
| Boiling point: | 196-198 °C(Press: 1 Torr) |
| Density | 1.136 g/mL at 25 °C |
| Flash point: | >110℃ |
| storage temp. | +2C to +8C |
| pka | 14.59±0.10(Predicted) |
| form | liquid |
| color | viscous |
| Sensitive | air sensitive |
| InChI | InChI=1S/C9H21O3P/c10-4-1-7-13(8-2-5-11)9-3-6-12/h10-12H,1-9H2 |
Safety information for Tris(hydroxypropyl)phosphine
| Signal word | Danger |
| Pictogram(s) |
 Corrosion Corrosives GHS05 |
| GHS Hazard Statements |
H314:Skin corrosion/irritation |
| Precautionary Statement Codes |
P280:Wear protective gloves/protective clothing/eye protection/face protection. P310:Immediately call a POISON CENTER or doctor/physician. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for Tris(hydroxypropyl)phosphine
| InChIKey | YICAEXQYKBMDNH-UHFFFAOYSA-N |
| SMILES | P(CCCO)(CCCO)CCCO |
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