Tris(2-(2-methoxyethoxy)ethyl)amine

Synonym(s):TDA-1;Tris(3,6-dioxaheptyl)amine

CAS NO.：70384-51-9
Empirical Formula: C15H33NO6
Molecular Weight: 323.43
MDL number: MFCD00010748
EINECS: 274-590-5
SAFETY DATA SHEET (SDS)
Update Date: 2025-09-25 17:15:13

Tris(2-(2-methoxyethoxy)ethyl)amine Structural

What is Tris(2-(2-methoxyethoxy)ethyl)amine?

Chemical properties

CLEAR PALE YELLOW TO BROWN LIQUID.
soluble in water, alcohol, ethers, and most organic solvents.

The Uses of Tris(2-(2-methoxyethoxy)ethyl)amine

Tris[2-(2-methoxyethoxy)ethyl]amine was used:

in oxidation of arylmethanols under phase-transfer conditions
as cryptand during phase-transfer glycosylation of 2-amino-4-methoxy-7H-pyrrolo[2,3-d]pyrimidine
as phase-transfer catalyst in synthesis of 1,3-dideaza-2′-deoxyadenosine and related benzimidazole 2′-deoxyribonucleosides

Synthesis

Tris(2-(2-methoxyethoxy)ethyl)amine was prepared by the reaction of 2-(2-methoxy-ethoxy)ethanol with a mixture of ammonia gas and hydrogen gas in the presence of catalytic amounts of Raney nickel.

Properties of Tris(2-(2-methoxyethoxy)ethyl)amine

Melting point:	<-100°C
Boiling point:	330 °C
Density	1.011 g/mL at 25 °C(lit.)
refractive index	n20/D 1.4486(lit.)
Flash point:	>230 °F
storage temp.	Inert atmosphere,Room Temperature
form	Liquid
pka	6.92±0.50(Predicted)
color	Clear pale yellow to brown
Water Solubility	miscible
Sensitive	Air Sensitive & Hygroscopic
BRN	2369296
CAS DataBase Reference	70384-51-9(CAS DataBase Reference)
NIST Chemistry Reference	Tris[2-(2-methoxyethoxy)ethyl]amine(70384-51-9)
EPA Substance Registry System	Ethanamine, 2-(2-methoxyethoxy)-N,N-bis[2-(2-methoxyethoxy)ethyl]- (70384-51-9)

Safety information for Tris(2-(2-methoxyethoxy)ethyl)amine

Signal word	Danger
Pictogram(s)	Corrosion Corrosives GHS05
GHS Hazard Statements	H314:Skin corrosion/irritation
Precautionary Statement Codes	P280:Wear protective gloves/protective clothing/eye protection/face protection. P363:Wash contaminated clothing before reuse. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up.