Trifluoromethylthiobenzene
Synonym(s):[(Trifluoromethyl)thio]benzene;Trifluoromethyl phenyl thioether
- CAS NO.：456-56-4
- Empirical Formula: C7H5F3S
- Molecular Weight: 178.17
- MDL number: MFCD00040839
- EINECS: 207-270-0
- SAFETY DATA SHEET (SDS)
- Update Date: 2025-09-25 17:15:13
What is Trifluoromethylthiobenzene?
The Uses of Trifluoromethylthiobenzene
Phenyl trifluoromethyl sulfide may be used in the preparation of:
- sulfoxides, dithiane dioxide, and dithiolane dioxide via iron-catalyzed oxidation of sulfides, dithiane, or dithiolane with hydrogen peroxide
- benzophenone hydrazone derivatives
- trifluoro- and difluoromethylsilanes by reductive coupling of fluoromethyl sulfones, sulfoxides and sulfides with chlorosilanes
Synthesis Reference(s)
The Journal of Organic Chemistry, 50, p. 4047, 1985 DOI: 10.1021/jo00221a017
Synthesis, p. 721, 1975 DOI: 10.1055/s-1975-23905
General Description
Phenyl trifluoromethyl sulfide (PTFMS) is an aryl trifluoromethyl sulfide. PTFMS with (triethylgermyl)sodium forms a reagent system that has been employed for the trifluoromethylation of certain imines. The reaction between OH radical and PTFMS has been analyzed using pulse radiolysis technique and quantum chemical calculations.
Properties of Trifluoromethylthiobenzene
| Boiling point: | 142 °C (lit.) |
| Density | 1.249 g/mL at 25 °C (lit.) |
| refractive index | n |
| Flash point: | 100 °F |
| form | clear liquid |
| color | Colorless to Almost colorless |
| Sensitive | Stench |
| BRN | 2043134 |
| CAS DataBase Reference | 456-56-4(CAS DataBase Reference) |
| NIST Chemistry Reference | Phenyl trifluoromethyl sulfide(456-56-4) |
Safety information for Trifluoromethylthiobenzene
| Signal word | Warning |
| Pictogram(s) |
 Flame Flammables GHS02  Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H226:Flammable liquids H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for Trifluoromethylthiobenzene
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