Trifluoro-p-tolunitrile

Synonym(s):α,α,α-Trifluoro-p-tolunitrile

CAS NO.：455-18-5
Empirical Formula: C8H4F3N
Molecular Weight: 171.12
MDL number: MFCD00001826
EINECS: 207-239-1
SAFETY DATA SHEET (SDS)
Update Date: 2026-05-28 02:10:40

What is Trifluoro-p-tolunitrile?

Chemical properties

white to light yellow crystal powder

The Uses of Trifluoro-p-tolunitrile

4-(Trifluoromethyl)benzonitrile is used in the synthesis of quinazolines for amidines. Also used in the synthesis of s-transferase p1-1 and cancer cell proliferation.

What are the applications of Application

4-(Trifluoromethyl)benzonitrile is a key intermediate in the synthesis of fluvoxamine

General Description

4-(Trifluoromethyl)benzonitrile is a key intermediate in the synthesis of fluvoxamine. It participates in nickel-catalyzed arylcyanation reaction of 4-octyne.

Properties of Trifluoro-p-tolunitrile

Melting point:	39-41 °C(lit.)
Boiling point:	80-81 °C20 mm Hg(lit.)
Density	1.278 g/mL at 25 °C(lit.)
refractive index	n20/D 1.4583(lit.)
Flash point:	161 °F
storage temp.	Sealed in dry,Room Temperature
Water Solubility	Insoluble in water
solubility	soluble in Chloroform, Methanol
form	powder to lump to clear liquid
color	White or Colorless to Light yellow
Specific Gravity	1.278
Sensitive	Lachrymatory
BRN	2046478
CAS DataBase Reference	455-18-5(CAS DataBase Reference)
NIST Chemistry Reference	4-Trifluoromethylbenzoic acid nitrile(455-18-5)
EPA Substance Registry System	Benzonitrile, 4-(trifluoromethyl)- (455-18-5)

Safety information for Trifluoro-p-tolunitrile

Signal word	Danger
Pictogram(s)	Flame Flammables GHS02 Exclamation Mark Irritant GHS07
GHS Hazard Statements	H228:Flammable solids
Precautionary Statement Codes	P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P240:Ground/bond container and receiving equipment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.