Trifluoro-p-tolunitrile
Synonym(s):α,α,α-Trifluoro-p-tolunitrile
- CAS NO.：455-18-5
- Empirical Formula: C8H4F3N
- Molecular Weight: 171.12
- MDL number: MFCD00001826
- EINECS: 207-239-1
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-27 10:43:30
What is Trifluoro-p-tolunitrile?
Chemical properties
white to light yellow crystal powder
The Uses of Trifluoro-p-tolunitrile
4-(Trifluoromethyl)benzonitrile is used in the synthesis of quinazolines for amidines. Also used in the synthesis of s-transferase p1-1 and cancer cell proliferation.
What are the applications of Application
4-(Trifluoromethyl)benzonitrile is a key intermediate in the synthesis of fluvoxamine
General Description
4-(Trifluoromethyl)benzonitrile is a key intermediate in the synthesis of fluvoxamine. It participates in nickel-catalyzed arylcyanation reaction of 4-octyne.
Properties of Trifluoro-p-tolunitrile
| Melting point: | 39-41 °C(lit.) |
| Boiling point: | 80-81 °C20 mm Hg(lit.) |
| Density | 1.278 g/mL at 25 °C(lit.) |
| refractive index | n |
| Flash point: | 161 °F |
| storage temp. | Sealed in dry,Room Temperature |
| Water Solubility | Insoluble in water |
| solubility | soluble in Chloroform, Methanol |
| form | powder to lump to clear liquid |
| color | White or Colorless to Light yellow |
| Specific Gravity | 1.278 |
| Sensitive | Lachrymatory |
| BRN | 2046478 |
| CAS DataBase Reference | 455-18-5(CAS DataBase Reference) |
| NIST Chemistry Reference | 4-Trifluoromethylbenzoic acid nitrile(455-18-5) |
| EPA Substance Registry System | Benzonitrile, 4-(trifluoromethyl)- (455-18-5) |
Safety information for Trifluoro-p-tolunitrile
| Signal word | Danger |
| Pictogram(s) |
 Flame Flammables GHS02  Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H228:Flammable solids |
| Precautionary Statement Codes |
P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P240:Ground/bond container and receiving equipment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. |
Computed Descriptors for Trifluoro-p-tolunitrile
| InChIKey | DRNJIKRLQJRKMM-UHFFFAOYSA-N |
New Products
Cyclopropane-1,1-dicarboxylic acid Cyclopentane-1,2-dione 2-Bromo-5-iodopyridine 4-isothiocyanato-2-(trifluoroMethyl)benzonitrile Amino-4-methoxyben-zeneacetic acid 3-Aminophenylacetic acid 1-AMino-cyclobutaneMethanol HCl (RS)-beta-Amino-beta-(4-bromophenyl)propionic acid Cefuroxime EP Impurity-A N-Nitroso hydroxy Cetrizine EP Impurity-A Noradrenaline EP Impurity D/Noradrenaline Methyl Ether Cetirizine EP Impurity A/Cetirizine CBHP Impurity Lantanoprost rc B Clidinium Bromide Impurity 3-Hydroxypropionitrile valeronitrile 3,4 Dimethoxy Benzylcyanide 3-chlorobenzyl cyanide 2-Chloro Benzylcyanide 4-Bromo Benzylcyanide 5-azidovalericacid 4-bromo-1H-pyrazole-3-carboxylic acid Isopropyl amine Hydrochloride tert-butyl 4-(6-(8-cyclopentyl-5-methyl-7-oxo-6-vinyl-7,8-dihydropyrido[2,3-d]pyrimidin-2-ylamino)pyridin-3-yl)piperazine-1-carboxylateRelated products of tetrahydrofuran
![1-[(AMMONIOOXY)METHYL]-4-(TRIFLUOROMETHYL)BENZENE CHLORIDE](https://img.chemicalbook.in/StructureFile/ChemBookStructure2/GIF/CB5266816.gif)
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