Triethyl 2-fluoro-2-phosphonoacetate
Synonym(s):2-Fluoro-2-phosphonoacetic acid triethyl ester;Diethyl [(ethoxycarbonyl)fluoromethyl]phosphonate;Ethyl diethylphosphonofluoroacetate
- CAS NO.：2356-16-3
- Empirical Formula: C8H16FO5P
- Molecular Weight: 242.18
- MDL number: MFCD00134400
- EINECS: 627-648-2
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-13 11:27:13
What is Triethyl 2-fluoro-2-phosphonoacetate?
Chemical properties
clear colorless liquid
The Uses of Triethyl 2-fluoro-2-phosphonoacetate
Reactant for:
- Diels-Alder reactions
- Biosynthesis of terpene
- Stereoselective synthesis of unsaturated esters, fluorides and nitriles from the reactions of aldehydes and ketones using Wadsworth-Emmons phosphonates
- Synthesis of quinolones
- Horner-Wadsworth-Emmons asymmetric hydration
- Addition reactions and the subsequent application to click chemistry
- Asymmetric intermolecular Stetter reactions
Synthesis Reference(s)
The Journal of Organic Chemistry, 60, p. 4730, 1995 DOI: 10.1021/jo00120a014
Properties of Triethyl 2-fluoro-2-phosphonoacetate
| Boiling point: | 75 °C0.01 mm Hg(lit.) |
| Density | 1.194 g/mL at 25 °C(lit.) |
| refractive index | n |
| Flash point: | 165 °F |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| form | clear liquid |
| color | Colorless to Almost colorless |
| Specific Gravity | 1.194 |
| BRN | 1912161 |
| CAS DataBase Reference | 2356-16-3(CAS DataBase Reference) |
Safety information for Triethyl 2-fluoro-2-phosphonoacetate
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H227:Flammable liquids H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up. |
Computed Descriptors for Triethyl 2-fluoro-2-phosphonoacetate
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