trans-Abacavir-d4 Hydrochloride
- CAS NO.：1346605-40-0
- Empirical Formula: C14H19ClN6O
- Molecular Weight: 322.8
- MDL number: MFCD28138131
What is trans-Abacavir-d4 Hydrochloride?
The Uses of trans-Abacavir-d4 Hydrochloride
trans-Abacavir-d4 Hydrochloride is deuterium labeled trans-Abacavir Dihydrochloride (A104995), which is an impurity of Abacavir. Abacavir (A104990) is a carbocyclic 2''-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.
The Uses of trans-Abacavir-d4 Hydrochloride
The labelled trans-isomer of Abacavir (A104990), a nucleoside reverse transcriptase inhibitor (NRTI). Abacavir USP impurity.
What are the applications of Application
trans-Abacavir-d4 Hydrochloride is the labelled trans-isomer of Abacavir, a nucleoside reverse transcriptase inhibitor (NRTI)
Safety information for trans-Abacavir-d4 Hydrochloride
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