Tosyl azide

Synonym(s):p-Toluenesulfonazide solution;4-Methylbenzenesulfonyl azide solution;Tosyl azide solution

CAS NO.：941-55-9
Empirical Formula: C7H7N3O2S
Molecular Weight: 197.21
MDL number: MFCD00180767
EINECS: 213-381-5
SAFETY DATA SHEET (SDS)
Update Date: 2025-07-04 15:09:30

What is Tosyl azide?

Chemical properties

Colorless to slight yellow liquid

The Uses of Tosyl azide

4-Methylbenzenesulfonyl Azide can be used to target Bcl-2 family proteins to potentially treat cancer.

The Uses of Tosyl azide

p-Toluenesulfonyl azide solution can be employed as a reagent along with alkyne, and amine in the three-component coupling reaction for the synthesis of N-sulfonylamidines in presence of copper catalyst.
It can also be used in the synthesis of N-sulfonyl-1,2,3-triazoles by azide-alkyne cycloaddition reaction in the presence of copper catalyst.

The Uses of Tosyl azide

Used for the introduction of azide and diazo functional groups. It is also used as a nitrene source and as a substrate for [3+2] cycloaddition reactions.

Synthesis Reference(s)

Synthetic Communications, 17, p. 1015, 1987 DOI: 10.1080/00397918708063962
Tetrahedron Letters, 28, p. 5091, 1987 DOI: 10.1016/S0040-4039(00)95598-9

Properties of Tosyl azide

Melting point:	22 °C
Density	~0.90 g/mL at 20 °C
refractive index	n20/D 1.548
Flash point:	4℃
storage temp.	2-8°C
EPA Substance Registry System	Benzenesulfonyl azide, 4-methyl- (941-55-9)

Safety information for Tosyl azide

Signal word	Danger
Pictogram(s)	Flame Flammables GHS02 Skull and Crossbones Acute Toxicity GHS06 Health Hazard GHS08
GHS Hazard Statements	H225:Flammable liquids H300:Acute toxicity,oral H304:Aspiration hazard H315:Skin corrosion/irritation H336:Specific target organ toxicity,single exposure; Narcotic effects H373:Specific target organ toxicity, repeated exposure H412:Hazardous to the aquatic environment, long-term hazard
Precautionary Statement Codes	P201:Obtain special instructions before use. P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P273:Avoid release to the environment. P331:Do NOT induce vomiting. P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.