TOPOTECAN-D6
- CAS NO.：1044904-10-0
- Empirical Formula: C23H23N3O5
- Molecular Weight: 421.45
- SAFETY DATA SHEET (SDS)
- Update Date: 2025-08-20 16:56:10
What is TOPOTECAN-D6?
Description
Topotecan-d6 is intended for use as an internal standard for the quantification of topotecan by GC- or LC-MS. Topotecan is an inhibitor of DNA topoisomerase I and a derivative of the DNA topoisomerase I inhibitor camptothecin . Topotecan inhibits DNA topoisomerase I in human MCF-7 breast and DU145 prostate cancer cells with IC50 values of 13 and 2 nM, respectively, in a cell-based luciferase reporter assay. Topotecan induces cytotoxicity and DNA damage in HT-29 human colon adenocarcinoma cells (IC50s = 33 and 280 nM, respectively). Formulations containing topotecan have been used in the treatment of small-cell lung cancer.
Chemical properties
Light Yellow to Greenish Powder
The Uses of TOPOTECAN-D6
Labelled Topotecan. A DNA topoisomerase I inhibitor; semisynthetic analog of Camptothecin. Antineoplastic
The Uses of TOPOTECAN-D6
Labelled Topotecan (T542500). A DNA topoisomerase I inhibitor; semisynthetic analog of Camptothecin. Antineoplastic.
What are the applications of Application
Topotecan-d6 is a labeled DNA Topo I (topoisomerase I) inhibitor
Properties of TOPOTECAN-D6
| Melting point: | 213-218°C (dec) |
| storage temp. | -20°C Freezer |
| solubility | aqueous acid: soluble; DMSO: slightly; Methanol: soluble |
| form | A solid |
| color | Light yellow to yellow |
| Stability: | Hygroscopic |
| CAS DataBase Reference | 1044904-10-0 |
Safety information for TOPOTECAN-D6
Computed Descriptors for TOPOTECAN-D6
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