TOPO II, P170 HUMAN
Synonym(s):TOPO II, p170;Topoisomerase II alpha
- Molecular Weight: 0
- MDL number: MFCD03458766
- Update Date: 2025-01-27 09:38:02
What is TOPO II, P170 HUMAN?
The Uses of TOPO II, P170 HUMAN
Human topoisomerase II α has been used in DNA cleavage assay.
General Description
Topoisomerase II α is encoded by TOP2A gene, which is located on 17q21.2 in the human chromosome. It is essential for controlling the topological state of DNA by reversibly breaking the DNA strands during replication, recombination and transcription. TOP2A expression increases at late S phase and during G2/M of the cell cycle and decreases after mitosis. Polymorphism with TOP2A causes chromosome instability and tumorigenesis. TOP2A causes tumor proliferation and invasiveness in various cancer types like breast cancer, ovarian cancer and prostate cancer.
Biochem/physiol Actions
Used to study DNA structure and topology.
Properties of TOPO II, P170 HUMAN
| storage temp. | −70°C |
| form | liquid |
Safety information for TOPO II, P170 HUMAN
Computed Descriptors for TOPO II, P170 HUMAN
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