TINZAPARIN SODIUM

The Uses of TINZAPARIN SODIUM

Innohep (Pharmion).

Clinical Use

Peri- and postoperative surgical thromboprophylaxis
Treatment of DVT and pulmonary embolism
Prevention of thrombus formation in extracorporeal circulation during HD

Drug interactions

Potentially hazardous interactions with other drugs
Analgesics: increased risk of bleeding with NSAIDs - avoid concomitant use with IV diclofenac; increased risk of haemorrhage with ketorolac - avoid concomitant use.
Nitrates: anticoagulant effect reduced by infusions of glyceryl trinitrate.
Use with care in patients receiving oral anticoagulants, platelet aggregation inhibitors, aspirin or dextran.

Metabolism

Low molecular weight heparins are partially metabolised by desulphation and depolymerisation. The kidneys are the major site of tinzaparin excretion (approximately 70
% based on animal studies).