Tiapride hydrochloride

Chemical properties

White Solid

Originator

Tiapridal,Delagrange,France,1977

The Uses of Tiapride hydrochloride

Tiapride hydrochloride is a D2 and D3 dopamine receptor antagonist and a antipsychotic drug predominately used in the pharmacotherapy of patients with dementia.

The Uses of Tiapride hydrochloride

Dopamine antagonist;Antidyskinetic

The Uses of Tiapride hydrochloride

Tiapride is a D2 and D3 dopamine receptor antagonist and a antipsychotic drug predominately used in the pharmacotherapy of patients with dementia.

What are the applications of Application

Tiapride hydrochloride is a D2DR and D3DR inhibitor

Definition

ChEBI: Tiapride hydrochloride is a member of benzamides.

Manufacturing Process

5 g of 2-methoxy-5-methylsulfonylbenzoic acid, 50 ml of dioxan, 3.02 ml of triethylamine and 3 g of isobutyl chloroformate were introduced into a 250 ml balloon flask at ambient temperature.
After the mixture had been stirred for 30 minutes, 3 g of N,N_x0002_diethylethylenediamine were added. The reaction mixture was stirred for 6 hours and the solvents were evaporated under vacuum.
The residue was dissolved in 50 ml of water and the solution was made alkaline with sodium hydroxide. The precipitate formed was filtered, washed and dried in a drying oven at 60°C. 6 g of N-(diethylaminoethyl)-2-methoxy- 5-methylsulfonylbenzamide (melting point: 124°C to 125°C) was produced.

Therapeutic Function

Antiemetic