Thiomorpholine
Synonym(s):Tetrahydro-2H-1,4-thiazine;Thiamorpholine
- CAS NO.：123-90-0
- Empirical Formula: C4H9NS
- Molecular Weight: 103.19
- MDL number: MFCD00005974
- EINECS: 204-660-2
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-13 11:18:12
What is Thiomorpholine?
Chemical properties
Clear colorless to yellow liquid
The Uses of Thiomorpholine
Organic synthesis.
The Uses of Thiomorpholine
Thiomorpholine is used as an intermediate for blonanserin. It is used in the preparation of pyrrole derivatives, which acts as a antimycobacterial agent. It is further involved in the hypocholesterolemic activity.
Definition
ChEBI: A saturated organic heteromonocyclic parent that is an analogue of morpholine where the oxygen atom is replaced by sulfur.
General Description
Thiomorpholine forms complexes with Cu(II), Pt(II) and Ni(II) salts and their catalytic activity has been investigated.
Purification Methods
Purify it by vacuum distillation. The hydrochloride has m 179o (from isoPrOH or EtOH/Et2O/HCl). [Davies J Chem Soc 306 1920, Beilstein 27 II 4, 2 III/IV 636.]
Properties of Thiomorpholine
| Melting point: | 166-168 |
| Boiling point: | 169 °C (lit.) |
| Density | 1.026 g/mL at 25 °C (lit.) |
| refractive index | n |
| Flash point: | 140 °F |
| storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
| solubility | organic solvents: miscible(lit.) |
| form | clear liquid |
| pka | 9.14±0.20(Predicted) |
| color | Colorless to Light yellow to Light orange |
| Water Solubility | Miscible with waterMiscible with water and organic solvents. |
| Sensitive | Air Sensitive |
| Merck | 14,9300 |
| BRN | 102550 |
| CAS DataBase Reference | 123-90-0(CAS DataBase Reference) |
| NIST Chemistry Reference | Thiomorpholine(123-90-0) |
Safety information for Thiomorpholine
| Signal word | Danger |
| Pictogram(s) |
 Corrosion Corrosives GHS05 |
| GHS Hazard Statements |
H314:Skin corrosion/irritation |
| Precautionary Statement Codes |
P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P330+P331:IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P501:Dispose of contents/container to..… |
Computed Descriptors for Thiomorpholine
| InChIKey | BRNULMACUQOKMR-UHFFFAOYSA-N |
Thiomorpholine manufacturer
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