Thiol-PEG6-t-butyl ester
- CAS NO.：1818294-40-4
- Empirical Formula: C19H38O8S
- Molecular Weight: 426.57
- MDL number: MFCD26127815
- Update Date: 2025-04-17 18:22:24
What is Thiol-PEG6-t-butyl ester?
Biological Activity
HS-PEG6-CH2CH2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References
[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
Properties of Thiol-PEG6-t-butyl ester
| Boiling point: | 488.8±45.0 °C(Predicted) |
| Density | 1.072±0.06 g/cm3(Predicted) |
| pka | 9?+-.0.10(Predicted) |
Safety information for Thiol-PEG6-t-butyl ester
Computed Descriptors for Thiol-PEG6-t-butyl ester
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