Tetraisopropyl methylenediphosphonate
- CAS NO.：1660-95-3
- Empirical Formula: C13H30O6P2
- Molecular Weight: 344.32
- MDL number: MFCD00015021
- EINECS: 216-765-0
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-05-27 22:54:05
What is Tetraisopropyl methylenediphosphonate?
Chemical properties
Clear colorless to slightly yellow liquid
The Uses of Tetraisopropyl methylenediphosphonate
Tetraisopropyl Methylenediphosphonate is used in the preparation of E2-bisphosphonate conjugates as potential anti-osteoporosis agents. Also used in the preparation of AZT 5’-Triphosphate compounds which display inhibitory effects on HIV-1 reverse transcrpitase.
The Uses of Tetraisopropyl methylenediphosphonate
Tetraisopropyl methylenediphosphonate [T(iPr)MDP] forms a synergistic mixture with hydrogen dicarbollylcobaltate in nitrobenzene which was used in the extraction of europium and americium.
It may be used in the synthesis of the following:
- tetraisopropyl ethenylidenebisphosphonate.
- tetraisopropyl 4-acetylthiobutane-1,1-diphosphonate
- tetraisopropyl 2-(3,5-bis(bromomethyl)phenyl)ethane-1,1-diphosphonate
What are the applications of Application
Tetraisopropyl methylenediphosphonate is used in the preparation of AZT 5′-Triphosphate compounds
General Description
Tetraisopropyl methylenediphosphonate (IPCP) is a tetraisopropyl ester of methylenediphosphonic acid. It is an electroneutral ligand, reported to be synthesized from triisopropyl phosphate. Powder electron paramagnetic resonance (EPR) studies of tris complexes of Cu(II) complexes with IPCP has been analyzed.
Properties of Tetraisopropyl methylenediphosphonate
| Boiling point: | 155 °C/0.5 mmHg (lit.) |
| Density | 1.08 g/mL at 25 °C (lit.) |
| vapor pressure | 0.017Pa at 20℃ |
| refractive index | n |
| Flash point: | 320 °F |
| storage temp. | -20°C |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| form | neat |
| color | Clear Colourless to Yellow |
| Specific Gravity | 1.080 |
| Water Solubility | Insoluble in water. |
| BRN | 1080180 |
| CAS DataBase Reference | 1660-95-3(CAS DataBase Reference) |
| NIST Chemistry Reference | Tetraisopropyl methylenediphosphonate(1660-95-3) |
| EPA Substance Registry System | Phosphonic acid, methylenebis-, tetrakis(1-methylethyl) ester (1660-95-3) |
Safety information for Tetraisopropyl methylenediphosphonate
| Signal word | Danger |
| Pictogram(s) |
 Corrosion Corrosives GHS05 |
| GHS Hazard Statements |
H318:Serious eye damage/eye irritation |
| Precautionary Statement Codes |
P280:Wear protective gloves/protective clothing/eye protection/face protection. |
Computed Descriptors for Tetraisopropyl methylenediphosphonate
| InChIKey | FKHXXJRKGVDPQP-UHFFFAOYSA-N |
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