Tetrafluoro-1-propanol

CAS NO.：76-37-9
Empirical Formula: C3H4F4O
Molecular Weight: 132.06
MDL number: MFCD00004676
EINECS: 200-955-5
SAFETY DATA SHEET (SDS)
Update Date: 2025-09-25 17:15:13

What is Tetrafluoro-1-propanol?

Chemical properties

colourless liquid

The Uses of Tetrafluoro-1-propanol

2,2,3,3-Tetrafluoro-1-propanol, is used as an essential fluorinated fine chemical, the main application of TFP is as a dye solvent in CD-R(W) and DVD-R(W) industry. It is also used in making textile treatment agent and pharmaceuticals. This chemical is an ideal replacement for Freon 22 detergent.

General Description

2,2,3,3-Tetrafluoro-1-propanol (TFP) is extensively used as the solvent. Mineralization and defluoridation of TFP by UV oxidation in a novel three-phase fluidized bed reactor was reported. Desorption of activated carbon loaded with TFP by supercritical carbon dioxide in a rotating packed bed was investigated.

Purification Methods

Tetrafluoro-1-propanol (450mL) is added to a solution of 2.25g of NaHSO3 in 90mL of water, shaken vigorously and set aside for 24hours. The fraction distilling at or above 99o is refluxed for 4hours with 5-6g of KOH and rapidly distilled, followed by a final fractional distillation. [Kosower & Wu J Am Chem Soc 83 3142 1961.] Alternatively, shake the alcohol with alumina for 24hours, dry it overnight with anhydrous K2CO3 and distil it, taking the middle fraction (b 107-108o). [Beilstein 1 IV 2438.]

Properties of Tetrafluoro-1-propanol

Melting point:	-15°C
Boiling point:	109 °C
Density	1.48 g/mL at 20 °C(lit.)
refractive index	n20/D 1.321(lit.)
Flash point:	110 °F
storage temp.	Sealed in dry,2-8°C
form	Liquid
pka	13.05±0.10(Predicted)
Specific Gravity	1.481.471
color	Clear colorless
Water Solubility	Soluble in water.
Merck	14,9206
BRN	1738264
Stability:	Stable. Flammable. Incompatible with strong oxidizing agents, strong bases, sodium, potassium, acid chlorides, acid anhydrides.
CAS DataBase Reference	76-37-9(CAS DataBase Reference)
NIST Chemistry Reference	2,2,3,3-Tetrafluoro-1-propanol(76-37-9)
EPA Substance Registry System	1-Propanol, 2,2,3,3-tetrafluoro- (76-37-9)

Safety information for Tetrafluoro-1-propanol

Signal word	Danger
Pictogram(s)	Flame Flammables GHS02 Skull and Crossbones Acute Toxicity GHS06
GHS Hazard Statements	H226:Flammable liquids H319:Serious eye damage/eye irritation H331:Acute toxicity,inhalation
Precautionary Statement Codes	P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.